Varaico: Literature-Extracted Genetic Variants

Gene:MET
Variant:p.R970C
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MET

NM_000245.4:p.R970C

Associated Papers

Circulating cell-free DNA profiling reveals ancestry-dependent genetic variation in metastatic prostate cancer.

Maleknia S et al.

Molecular Biomedicine, 2026

41673362 (PubMed )
Supplement: 43556_2026_405_MOESM2_ESM.xlsx › cfDNA_Variants

Clinical utility of liquid biopsy next-generation sequencing for advanced non-small cell lung cancer in the Netherlands.

de Bitter TJJ et al.

Scientific Reports, 2025

40830613 (PubMed )
Supplement: 41598_2025_13667_MOESM2_ESM.xlsx › Supplementary_Table_3

Towards Personalized Precision Oncology: A Feasibility Study of NGS-Based Variant Analysis of FFPE CRC Samples in a Chilean Public Health System Laboratory.

Durán-Jara E et al.

Current Issues in Molecular Biology, 2025

40864753 (PubMed )
Supplement: cimb-47-00599-s001.zip › Supplementary_Table_S4_-_VAF_and_actionability.pdf

Comprehensive mapping elucidates high risk genotypes in primary metastatic breast cancer.

Berg T et al.

Neoplasia (new York, N.y.), 2025

40121945 (PubMed )
Supplement: mmc5.xlsx › Ark1

Expert consensus on the diagnosis and treatment of non-small cell lung cancer with MET alteration.

Feng H et al.

Cancer Biology & Medicine, 2025

Endometrial carcinomas with ambiguous histology often harbor TP53 mutations.

Davidson B et al.

Virchows Archiv : an International Journal of Pathology, 2025

39235515 (PubMed )
Supplement: 428_2024_3912_MOESM1_ESM.xlsx › Mutation_list

Comparative analysis of whole-genome sequencing of tumor and cfDNA in a neuroblastoma patient: a case report.

Fransson S et al.

Frontiers in Oncology, 2025

Therapeutic advances of targeting receptor tyrosine kinases in cancer.

Tomuleasa C et al.

Signal Transduction and Targeted Therapy, 2024

Recording and classifying MET receptor mutations in cancers.

Guérin C et al.

Elife, 2024

The genomic and evolutionary landscapes of anaplastic thyroid carcinoma.

Zeng PYF et al.

Cell Reports, 2024

38412093 (PubMed )
Supplement: NIHMS1980905-supplement-9.xlsx › SuppTable4b.Germline_Data

Development, testing and validation of a targeted NGS-panel for the detection of actionable mutations in lung cancer (NSCLC) using anchored multiplex PCR technology in a multicentric setting.

Kumbrink J et al.

Pathology Oncology Research : Por, 2024

38605929 (PubMed )
Supplement: Table1.XLSX › Sup_Table_1_Comparison_details

Next generation sequencing and genomic mapping: towards precision molecular diagnosis of lung cancer in Morocco.

Morjani O et al.

The Pan African Medical Journal, 2024

Protein Tyrosine Phosphatase Non-Receptor 11 (PTPN11/Shp2) as a Driver Oncogene and a Novel Therapeutic Target in Non-Small Cell Lung Cancer (NSCLC).

Richards CE et al.

International Journal of Molecular Sciences, 2023

37445722 (PubMed )
Supplement: ijms-24-10545-s001.zip › PTPN11_paper_supplementary_tables_25042023.pdf

Targeted deep sequencing reveals genomic alterations of actinic keratosis/cutaneous squamous cell carcinoma in situ and cutaneous squamous cell carcinoma.

Kim YS et al.

Experimental Dermatology, 2023

Atypical thymomas with squamoid and spindle cell features: clinicopathologic, immunohistochemical and molecular genetic study of 120 cases with long-term follow-up.

Suster DI et al.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 2022

Association of single nucleotide polymorphisms in the CAPN, CAST, LEP, GH, and IGF-1 genes with growth parameters and ultrasound characteristics of the Longissimus dorsi muscle in Colombian hair sheep.

Valencia CPL et al.

Tropical Animal Health and Production, 2022

Combined multimodal ctDNA analysis and radiological imaging for tumor surveillance in Non-small cell lung cancer.

Metzenmacher M et al.

Translational Oncology, 2022

34800919 (PubMed )
Supplement: mmc3.xlsx › Tabelle1

Orthogonal MET analysis in a population-representative stage II-III colon cancer cohort: prognostic and potential therapeutic implications.

Craig SG et al.

Molecular Oncology, 2021

Genomic Alterations in Human Papillomavirus-Positive and -Negative Conjunctival Squamous Cell Carcinomas.

Ramberg I et al.

Investigative Ophthalmology & Visual Science, 2021

34779821 (PubMed )
Supplement: iovs-62-14-11_s001.pdf

MET Mutation Is a Potential Therapeutic Target for Advanced Endometrial Cancer.

Yeh YM et al.

Cancers, 2021

34439385 (PubMed )
Supplement: cancers-13-04231-s001.zip › cancers-1323092-supplementary-proof › supplementary › Supplementary_Figure_S2.pdf

Enhanced specificity of clinical high-sensitivity tumor mutation profiling in cell-free DNA via paired normal sequencing using MSK-ACCESS.

Rose Brannon A et al.

Nature Communications, 2021

34145282 (PubMed )
Supplement: 41467_2021_24109_MOESM4_ESM.xlsx › Supplementary_Data_1

MET-dependent solid tumours - molecular diagnosis and targeted therapy.

Guo R et al.

Nature Reviews. Clinical Oncology, 2020

Identification of MicroRNA-Related Tumorigenesis Variants and Genes in the Cancer Genome Atlas (TCGA) Data.

Li C et al.

Genes, 2020

32824926 (PubMed )
Supplement: genes-11-00953-s001.zip › Table_S4.xlsx › Sheet1

Molecular matching and treatment strategies for advanced stage lung cancer at Dartmouth-Hitchcock Medical Center: A three-year review of a Molecular Tumor Board.

Bernhardt EB et al.

Practical Laboratory Medicine, 2020

Rare Tumor-Normal Matched Whole Exome Sequencing Identifies Novel Genomic Pathogenic Germline and Somatic Aberrations.

Sprissler R et al.

Cancers, 2020

32570879 (PubMed )
Supplement: cancers-12-01618-s001.zip › cancers-817200-Supplementary_Materials3 › Supplementary_table_S1.xlsx › Oncogenes

Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study.

Rothwell DG et al.

Nature Medicine, 2019

RAS Mutation in Mucinous Carcinoma of the Ovary

Panyavaranant P et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2019

Cystic Hygroma: A Preliminary Genetic Study and a Short Review from the Literature.

Noia G et al.

Lymphatic Research and Biology, 2019

Genetic Mutations in a Patient with Chronic Myeloid Leukemia Showing Blast Crisis 10 Years After Presentation.

Sklarz LM et al.

Anticancer Research, 2018

Molecular Screening of Small Biopsy Samples Using Next-Generation Sequencing in Korean Patients with Advanced Non-small Cell Lung Cancer: Korean Lung Cancer Consortium (KLCC-13-01).

Ku BM et al.

Journal of Pathology and Translational Medicine, 2018

Unexpected cancer-predisposition gene variants in Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome patients without underlying germline PTEN mutations.

Yehia L et al.

Plos Genetics, 2018

29684080 (PubMed )
Supplement: pgen.1007352.s009.xlsx › S8_Table

Molecular alterations in lesions of anogenital mammary-like glands and their mammary counterparts including hidradenoma papilliferum, intraductal papilloma, fibroadenoma and phyllodes tumor.

Konstantinova AM et al.

Annals of Diagnostic Pathology, 2017

Exon 14 Deleted MET Receptor as a New Biomarker and Target in Cancers.

Cortot AB et al.

Journal of the National Cancer Institute, 2017

MET in human cancer: germline and somatic mutations.

Tovar EA et al.

Annals of Translational Medicine, 2017

MET receptor variant R970C favors calpain-dependent generation of a fragment promoting epithelial cell scattering.

Montagne R et al.

Oncotarget, 2017

Potential pitfalls of mass spectrometry to uncover mutations in childhood soft tissue sarcoma: A report from the Children's Oncology Group.

Xu L et al.

Scientific Reports, 2016

Determination of somatic oncogenic mutations linked to target-based therapies using MassARRAY technology.

Ibarrola-Villava M et al.

Oncotarget, 2016

Overexpression of wildtype EGFR is tumorigenic and denotes a therapeutic target in non-small cell lung cancer.

Xu N et al.

Oncotarget, 2016

26646697 (PubMed )
Supplement: oncotarget-07-3884-s001.pdf

Maxillary carcinosarcoma: Identification of a novel MET mutation in both carcinomatous and sarcomatous components through next generation sequencing.

Ando M et al.

Head & Neck, 2015

Kinome sequencing reveals RET G691S polymorphism in human neuroendocrine lung cancer cell lines.

Sosonkina N et al.

Genes & Genomics, 2014

Concurrent oncogene mutation profile in Chinese patients with stage Ib lung adenocarcinoma.

Wen YS et al.

Medicine, 2014

Hotspot mutations in common oncogenes are infrequent in nasopharyngeal carcinoma.

Jiang N et al.

Oncology Reports, 2014

RET mutation and expression in small-cell lung cancer.

Dabir S et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2014

Phenotypic drug screening and target validation for improved personalized therapy reveal the complexity of phenotype-genotype correlations in clear cell renal cell carcinoma.

Schneider M et al.

Urologic Oncology, 2014

Oncogene mutational profile in nasopharyngeal carcinoma.

Zhang ZC et al.

Oncotargets and Therapy, 2014

Identification of anaplastic lymphoma kinase break points and oncogenic mutation profiles in acral/mucosal melanomas.

Niu HT et al.

Pigment Cell & Melanoma Research, 2013

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."