Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

60 papers

NM_000245.4

p.R970C

c.2908C>T

NM_001127500.3

p.R988C

c.2962C>T

Surrounding Variants

1 paper

NM_000245.4

p.R970fs

c.2908_2909fs

2 papers

NM_000245.4

p.R970H

c.2909G>A

1 paper

NM_000245.4

p.R970R

c.2910C>T

1 paper

NM_000245.4

p.V969A

c.2906T>C

1 paper

NM_000245.4

p.V969_A973Fs

c.2906_2919delinsAGGAGTGTGTACFs

1 paper

NM_000245.4

p.V969I

c.2905G>A

1 paper

NM_000245.4

p.V969fs

c.2905_2906fs

2 papers

NM_001127500.3

p.Y989C

c.2966A>G

NM_000245.4

p.Y971C

c.2912A>G

1 paper

NM_000245.4

p.Y971F

c.2912A>T

1 paper

NM_000245.4

p.V969_L980del0

c.2905_2940del36

1 paper

NM_000245.4

p.Y971Y

c.2913C>T

1 paper

NM_000245.4

p.Y971_D972Fs

c.2913_2914delinsTFs