Varaico: Literature-Extracted Genetic Variants

Gene:MET
Variant:p.D1028N
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MET

NM_001127500.3:p.D1028N

Associated Papers

Scoring Reliability of c-Met Immunohistochemical Assays in Lung Adenocarcinoma.

Zhou Y et al.

Laboratory Investigation; a Journal of Technical Methods and Pathology, 2026

Discovery of Novel RASGRF2 Fusions as a Therapeutic Target in Lung Adenocarcinoma of Never or Light Smokers.

Terashima Y et al.

Cancer Science, 2025

40734624 (PubMed )
Supplement: CAS-116-2868-s002.xlsx › Table_S3

Clinical utility of liquid biopsy next-generation sequencing for advanced non-small cell lung cancer in the Netherlands.

de Bitter TJJ et al.

Scientific Reports, 2025

40830613 (PubMed )
Supplement: 41598_2025_13667_MOESM2_ESM.xlsx › Supplementary_Table_3

The Landscape of MET Exon 14 Skipping Mutations in Patients With Lung Cancer Identified by Next-Generation Sequencing.

Liao J et al.

Jto Clinical and Research Reports, 2025

Expert consensus on the diagnosis and treatment of non-small cell lung cancer with MET alteration.

Feng H et al.

Cancer Biology & Medicine, 2025

40200811 (PubMed )
Supplement: cbm-22-237-s001.pdf

Safety, Efficacy, and Biomarker Analysis of Crizotinib in MET-Mutated Non-Small Cell Lung Cancer-Results from the Drug Rediscovery Protocol.

Verkerk K et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2024

Targeted RNA Sequencing of Head and Neck Adenoid Cystic Carcinoma Reveals SEC16A::NOTCH1 Fusion and MET Exon 14 Skipping as Potentially Actionable Alterations.

Chu YH et al.

Head and Neck Pathology, 2024

Profiling Cell-Free DNA from Malignant Pleural Effusion for Oncogenic Driver Mutations in Patients with Treatment-Naive Stage IV Adenocarcinoma: A Multicenter Prospective Study.

Chang SC et al.

Molecular Diagnosis & Therapy, 2024

Molecular profiling METex14+ non-small cell lung cancer (NSCLC): Impact of histology.

Marks JA et al.

Lung Cancer (amsterdam, Netherlands), 2024

Whole-Exome Sequencing Reveals Novel Candidate Driver Mutations and Potential Druggable Mutations in Patients with High-Risk Neuroblastoma.

Nokchan N et al.

Journal of Personalized Medicine, 2024

39338204 (PubMed )
Supplement: jpm-14-00950-s001.zip › Supplementary_Table_S5.xlsx › Supplementary_Table_S5.

Molecular analysis of non-small cell lung cancer using a dual-targeted DNA and RNA comprehensive genomic profiling panel.

Kage H et al.

Respiratory Investigation, 2024

Intracranial response to capmatinib after progression on crizotinib in a patient with MET exon 14 skipping non-small cell lung cancer-a case report.

Jóri B et al.

Translational Lung Cancer Research, 2024

Genomic Landscape of Pulmonary Sarcomatoid Carcinoma.

Kwon HJ et al.

Cancer Research and Treatment, 2024

37973906 (PubMed )
Supplement: crt-2023-764-Supplementary-Table-S4.pdf

Identification of gene variation feature for targeted therapy of non-small cell lung cancer through combined method of DNA and RNA sequencing.

Pang W et al.

Discover Oncology, 2024

Chinese expert consensus on clinical practice of MET detection in non-small cell lung cancer.

Bai Q et al.

Therapeutic Advances in Medical Oncology, 2024

Combinatorial therapy is a safe and durable treatment option in ALK-rearranged non-small cell lung cancer with an acquired MET exon 14 skipping mutation mediated resistance to alectinib: a case report.

Jang C et al.

Translational Lung Cancer Research, 2023

Concordance between cancer gene alterations in tumor and circulating tumor DNA correlates with poor survival in a real-world precision-medicine population.

Rosenberg S et al.

Molecular Oncology, 2023

36694946 (PubMed )
Supplement: MOL2-17-1844-s003.xlsx › 2a.Studied_gene

Potent antitumor activity of ensartinib in MET exon 14 skipping-mutated non-small cell lung cancer.

Xia Y et al.

Cancer Letters, 2023

Optimized Detection of Unknown MET Exon 14 Skipping Mutations in Routine Testing for Patients With Non-Small-Cell Lung Cancer.

Sun R et al.

Jco Precision Oncology, 2023

MET Signaling Pathways, Resistance Mechanisms, and Opportunities for Target Therapies.

Rivas S et al.

International Journal of Molecular Sciences, 2022

Mutational Landscape and Expression of PD-L1 in Patients with Non-Small Cell Lung Cancer Harboring Genomic Alterations of the MET gene.

Fischer A et al.

Targeted Oncology, 2022

Identification of Novel MET Exon 14 Skipping Variants in Non-Small Cell Lung Cancer Patients: A Prototype Workflow Involving in Silico Prediction and RT-PCR.

Das R et al.

Cancers, 2022

Clinically actionable cancer somatic variants (CACSV): a tumor interpreted dataset for analytical workflows.

Sobahy TM et al.

Bmc Medical Genomics, 2022

35468810 (PubMed )
Supplement: 12920_2022_1235_MOESM2_ESM.xlsx › Sheet1

Variation in targetable genomic alterations in non-small cell lung cancer by genetic ancestry, sex, smoking history, and histology.

Adib E et al.

Genome Medicine, 2022

35428358 (PubMed )
Supplement: 13073_2022_1041_MOESM2_ESM.xlsx › S4_MET_Druggable

Clinical and pathological characteristics of 11 NSCLC patients with c-MET exon 14 skipping.

Chen H et al.

Translational Cancer Research, 2022

Targeting the tumor mutanome for personalized vaccination in a TMB low non-small cell lung cancer.

McCann K et al.

Journal for Immunotherapy of Cancer, 2022

Case Report: A Lung Adenocarcinoma With Brain Metastasis Harbored Novel MET 14 Skipping Alteration Sensitive to Savolitinib.

Li J et al.

Frontiers in Oncology, 2022

Non-small-cell lung cancer: how to manage MET exon 14 skipping mutant disease.

Blaquier JB et al.

Drugs in Context, 2022

Comprehensive analysis of MET mutations in NSCLC patients in a real-world setting.

Ai X et al.

Therapeutic Advances in Medical Oncology, 2022

Integrated Analysis of Genomic and Immunological Features in Lung Adenocarcinoma With Micropapillary Component.

Zhang S et al.

Frontiers in Oncology, 2021

34221970 (PubMed )
Supplement: Table_5.xlsx › Supplementary_Table_S5

Mesenchymal-Epithelial Transition Exon 14 Skipping Mutation and Amplification in 5,008 Patients With Lung Cancer.

Song Y et al.

Frontiers in Oncology, 2021

Landscape and Clonal Dominance of Co-occurring Genomic Alterations in Non-Small-Cell Lung Cancer Harboring MET Exon 14 Skipping.

Le X et al.

Jco Precision Oncology, 2021

Identifying Actionable Variants Using Capture-Based Targeted Sequencing in 563 Patients With Non-Small Cell Lung Carcinoma.

Jiang H et al.

Frontiers in Oncology, 2021

35186718 (PubMed )
Supplement: Table_1.xlsx › Supplementary_Table_2

Prolonged survival and response to tepotinib in a non-small-cell lung cancer patient with brain metastases harboring MET exon 14 mutation: a research report.

Roth KG et al.

Cold Spring Harbor Molecular Case Studies, 2020

Characterization of MET exon 14 alteration and association with clinical outcomes of crizotinib in Chinese lung cancers.

Yang H et al.

Lung Cancer (amsterdam, Netherlands), 2020

MET-dependent solid tumours - molecular diagnosis and targeted therapy.

Guo R et al.

Nature Reviews. Clinical Oncology, 2020

Molecular correlates of response to capmatinib in advanced non-small-cell lung cancer: clinical and biomarker results from a phase I trial.

Schuler M et al.

Annals of Oncology : Official Journal of the European Society for Medical Oncology, 2020

Impact and Diagnostic Gaps of Comprehensive Genomic Profiling in Real-World Clinical Practice.

Singh AP et al.

Cancers, 2020

Frequency of MET exon 14 skipping mutations in non-small cell lung cancer according to technical approach in routine diagnosis: results from a real-life cohort of 2,369 patients.

Champagnac A et al.

Journal of Thoracic Disease, 2020

Highly accurate DNA-based detection and treatment results of MET exon 14 skipping mutations in lung cancer.

Pruis MA et al.

Lung Cancer (amsterdam, Netherlands), 2020

Non-small cell lung cancer with mesenchymal-epithelial transition gene exon 14 skipping mutation treated with crizotinib.

Katakura S et al.

Respirology Case Reports, 2019

[Detection and interpretation of somatic variants in molecular pathology].

Merkelbach-Bruse S et al.

Der Pathologe, 2019

Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin-fixed paraffin-embedded specimens.

Kohsaka S et al.

Cancer Science, 2019

30737998 (PubMed )
Supplement: CAS-110-1464-s005.xlsx › Table_S4

Analysis of error profiles in deep next-generation sequencing data.

Ma X et al.

Genome Biology, 2019

30867008 (PubMed )
Supplement: 13059_2019_1659_MOESM1_ESM.xlsx › S3_b

Computational analysis reveals histotype-dependent molecular profile and actionable mutation effects across cancers.

Heim D et al.

Genome Medicine, 2018

30442178 (PubMed )
Supplement: 13073_2018_591_MOESM4_ESM.xlsx › Table_S2
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."