Varaico: Literature-Extracted Genetic Variants

Gene:MGMT
Variant:p.L84F
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MGMT

NM_002412.5:p.L84F

Associated Papers

Single-nucleotide polymorphisms in DNA repair genes ERCC, XRCC, and MGMT and implications in glioblastoma: a pathway analysis and structural dynamics study.

Afshar Y et al.

Journal of Biomolecular Structure & Dynamics, 2025

Molecular profile of adult primary leptomeningeal gliomatosis aligns with glioblastoma, IDH-wildtype.

Zhu Y et al.

Brain Pathology (zurich, Switzerland), 2025

Identifying active and inhibitor-resistant MGMT variants for gene therapy.

Cheong A et al.

American Journal of Human Genetics, 2025

Evaluation of mutations on O6-methylguanine methyl transferase structure and its interactions: molecular dynamics simulation study.

Gharouni M et al.

Journal of Biomolecular Structure & Dynamics, 2025

Integrative Computational Analysis of Common EXO5 Haplotypes: Impact on Protein Dynamics, Genome Stability, and Cancer Progression.

Mazza F et al.

Journal of Chemical Information and Modeling, 2025

40115981 (PubMed )
Supplement: ci5c00067_si_002.xlsx › scored_ALL_haplotypes_1MAF_cano

Reliable detection of genetic alterations in cyst fluid DNA for the diagnosis of brain tumors.

On J et al.

Journal of Neuro-oncology, 2024

Genotyping, in silico screening and molecular dynamics simulation of SNPs of MGMT and ERCC1 gene in lung cancer patients treated with platinum-based doublet chemotherapy.

Singh S et al.

Journal of Biomolecular Structure & Dynamics, 2024

New molecular prognostic factors of adult diffuse lower-grade gliomas in post-2016 molecular era: a retrospective analysis from single center.

Wang Q et al.

British Journal of Neurosurgery, 2023

Mutation analysis of the TERT gene in ovarian cancer patients of the Turkish population by next generation sequencing method.

Capar Gorali B et al.

Cellular and Molecular Biology (noisy-le-grand, France), 2023

Genetic and epigenetic alterations in MGMT gene and correlation with concomitant chemoradiotherapy (CRT) in cervical cancer.

Gupta MK et al.

Journal of Cancer Research and Clinical Oncology, 2023

Genomic profiles of IDH-mutant gliomas: MYCN-amplified IDH-mutant astrocytoma had the worst prognosis.

Lee K et al.

Scientific Reports, 2023

Brain radiotoxicity-related 15CAcBRT gene expression signature predicts survival prognosis of glioblastoma patients.

Reyes-González J et al.

Neuro-oncology, 2023

35802478 (PubMed )
Supplement: noac171_suppl_suplementary_table_s1.xlsx › Table_S1

Association of human telomerase reverse transcriptase promoter mutation with unfavorable prognosis in glioma: A systematic review and meta-analysis.

Hua R et al.

Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences, 2023

Age-associated mortality is partially mediated by TERT promoter mutation status in differentiated thyroid carcinoma.

Heo J et al.

Plos One, 2023

Genetic susceptibility of bladder cancer in the Lebanese population.

Kourie HR et al.

Bmc Medical Genomics, 2022

36253817 (PubMed )
Supplement: 12920_2022_1372_MOESM2_ESM.xlsx › Literature_review_table

Detection of TERT Promoter Mutations as a Prognostic Biomarker in Gliomas: Methodology, Prospects, and Advances.

Hasanau T et al.

Biomedicines, 2022

Temozolomide-induced myelotoxicity and single nucleotide polymorphisms in the MGMT gene in patients with adult diffuse glioma: a single-institutional pharmacogenetic study.

Moitra P et al.

Journal of Neuro-oncology, 2022

Detection of TERT Promoter Mutations Using Targeted Next-Generation Sequencing: Overcoming GC Bias through Trial and Error.

Lee H et al.

Cancer Research and Treatment, 2022

Gene polymorphisms and prognosis of head and neck squamous cell carcinoma: a systematic review.

Rajabi-Moghaddam M et al.

Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology, 2022

Gene polymorphisms and risk of head and neck squamous cell carcinoma: a systematic review.

Rajabi-Moghaddam M et al.

Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology, 2022

Single nucleotide polymorphisms and the risk of developing a second primary cancer among head and neck cancer patients: a systematic literature review and meta-analysis.

Hoxhaj I et al.

Bmc Cancer, 2021

Pathological characteristics, survival, and risk of breast cancer associated with estrogen and xenobiotic metabolism polymorphisms in Mexican women with breast cancer.

Martínez-Ramírez OC et al.

Cancer Causes & Control : Ccc, 2021

Establishment and Validation of the Detection of TERT Promoter Mutations by Human Gliomas U251 Cell Lines.

Bai H et al.

Biomed Research International, 2021

34159191 (PubMed )
Supplement: 3271395.f1.docx

Systematic meta-analyses, field synopsis and global assessment of the evidence of genetic association studies in colorectal cancer.

Montazeri Z et al.

Gut, 2020

31818908 (PubMed )
Supplement: gutjnl-2019-319313supp002.pdf

The Role of O6-methylguanine-DNA Methyltransferase Polymorphisms in Prostate Cancer Susceptibility: a Meta-Analysis.

Zhang W et al.

Pathology Oncology Research : Por, 2020

Association of DNA repair gene polymorphisms with colorectal cancer risk and treatment outcomes.

Al-Shaheri FN et al.

Experimental and Molecular Pathology, 2020

Cumulative Evidence for Associations between Genetic Variants and Risk of Esophageal Cancer.

Li G et al.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 2020

31969372 (PubMed )
Supplement: 10559965epi191281-sup-230715_3_supp_6000458_q3kstt.docx

Impact of rs12917 MGMT Polymorphism on [18F]FDG-PET Response in Pediatric Hodgkin Lymphoma (PHL).

Kewitz-Hempel S et al.

Molecular Imaging and Biology, 2019

Prognostic significance of human telomerase reverse transcriptase promoter region mutations C228T and C250T for overall survival in spinal chordomas.

Bettegowda C et al.

Neuro-oncology, 2019

Systematic Review of Genetic Factors in the Etiology of Esophageal Squamous Cell Carcinoma in African Populations.

Simba H et al.

Frontiers in Genetics, 2019

TERT Promoter Mutation Detection in Cell-Free Tumor-Derived DNA in Patients with IDH Wild-Type Glioblastomas: A Pilot Prospective Study.

Juratli TA et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2018

The potential role of MGMT rs12917 polymorphism in cancer risk: an updated pooling analysis with 21010 cases and 34018 controls.

Sheng Z et al.

Bioscience Reports, 2018

Cancer-driving H3G34V/R/D mutations block H3K36 methylation and H3K36me3-MutSα interaction.

Fang J et al.

Proceedings of the National Academy of Sciences of the United States of America, 2018

Human glioblastoma arises from subventricular zone cells with low-level driver mutations.

Lee JH et al.

Nature, 2018

The role of MGMT polymorphisms rs12917 and rs11016879 in head and neck cancer risk and prognosis.

Kiczmer P et al.

Acta Biochimica Polonica, 2018

Genetic polymorphisms and lung cancer risk: Evidence from meta-analyses and genome-wide association studies.

Liu C et al.

Lung Cancer (amsterdam, Netherlands), 2017

MGMT gene variants, temozolomide myelotoxicity and glioma risk. A concise literature survey including an illustrative case.

Altinoz MA et al.

Journal of Chemotherapy (florence, Italy), 2017

The PTPN13 Y2081D (T>G) (rs989902) polymorphism is associated with an increased risk of sporadic colorectal cancer.

Laczmanska I et al.

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland, 2017

Investigation of DNA repair-related SNPs underlying susceptibility to papillary thyroid carcinoma reveals MGMT as a novel candidate gene in Belarusian children exposed to radiation.

Lonjou C et al.

Bmc Cancer, 2017

28499365 (PubMed )
Supplement: 12885_2017_3314_MOESM1_ESM.xls › SupplTableS1.xls

Prognostic Relevance of Tumor Purity and Interaction with MGMT Methylation in Glioblastoma.

Schulze Heuling E et al.

Molecular Cancer Research : Mcr, 2017

Genetic and epigenetic stability of oligodendrogliomas at recurrence.

Aihara K et al.

Acta Neuropathologica Communications, 2017

The MGMT promoter single-nucleotide polymorphism rs1625649 had prognostic impact on patients with MGMT methylated glioblastoma.

Hsu CY et al.

Plos One, 2017

TERT promoter mutations and rs2853669 polymorphism: prognostic impact and interactions with common alterations in glioblastomas.

Nencha U et al.

Journal of Neuro-oncology, 2016

Clinical and Genetic Factors Associated With Severe Hematological Toxicity in Glioblastoma Patients During Radiation Plus Temozolomide Treatment: A Prospective Study.

Lombardi G et al.

American Journal of Clinical Oncology, 2015

Genetic Association Between Angiotensinogen Polymorphisms and Lung Cancer Risk.

Wang H et al.

Medicine, 2015

TERT promoter mutations and polymorphisms as prognostic factors in primary glioblastoma.

Mosrati MA et al.

Oncotarget, 2015

Genetic polymorphisms in DNA repair and oxidative stress pathways may modify the association between body size and postmenopausal breast cancer.

McCullough LE et al.

Annals of Epidemiology, 2015

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."