Varaico: Literature-Extracted Genetic Variants

MGMT

604 papers

RefSeq Summary

Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutag...

Pfam Domains

Methyltransf_1Naa 7–83UCSC6-O-methylguanine DNA methyltransferase, ribonuclease-like domain

DNA_binding_1aa 93–174UCSC6-O-methylguanine DNA methyltransferase, DNA binding domain

Gene Aliases

HGNC Name

O-6-methylguanine-DNA methyltransferase

HGNC Alias Name

methylated-DNA--protein-cysteine methyltransferase

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

161 papers

NM_002412.5

p.L84F

c.250C>T

Surrounding Variants

3 papers

NM_002412.5

p.V81M

c.241G>A

1 paper

NM_002412.5

p.V81L

c.241G>T

1 paper

NM_002412.5

p.P80P

c.240C>G

2 papers

NM_002412.5

p.P87L

c.260C>T

1 paper

NM_002412.5

p.P80delFs

c.240delC

1 paper

NM_002412.5

p.Q90P

c.269A>C

1 paper

NM_002412.5

p.Q90L

c.269A>T

13 papers

NM_002412.5

p.I76I

c.228C>T

1 paper

NM_002412.5

p.A75D

c.224C>A

1 paper

NM_002412.5

p.A75V

c.224C>T

1 paper

NM_002412.5

p.E92Splc

c.274+4G>A

1 paper

NM_002412.5

p.E74A

c.221A>C