Varaico: Literature-Extracted Genetic Variants

Gene:ODC1
Variant:p.K69R
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ODC1

NM_002539.3:p.K69R

Associated Papers

Multiple roles of the active site lysine of Dopa decarboxylase.

Bertoldi M et al.

Archives of Biochemistry and Biophysics, 2009

Ornithine decarboxylase promotes catalysis by binding the carboxylate in a buried pocket containing phenylalanine 397.

Jackson LK et al.

Biochemistry, 2003

Altering the reaction specificity of eukaryotic ornithine decarboxylase.

Jackson LK et al.

Biochemistry, 2000

Lysine-69 plays a key role in catalysis by ornithine decarboxylase through acceleration of the Schiff base formation, decarboxylation, and product release steps.

Osterman AL et al.

Biochemistry, 1999

Effect of mutations at active site residues on the activity of ornithine decarboxylase and its inhibition by active site-directed irreversible inhibitors.

Coleman CS et al.

The Journal of Biological Chemistry, 1993

Dominant negative mutants of ornithine decarboxylase.

Tsirka S et al.

The Journal of Biological Chemistry, 1992

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."