Varaico: Literature-Extracted Genetic Variants

Gene:PIK3CA
Variant:p.T1025T
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PIK3CA

NM_006218.4:p.T1025T

Associated Papers

Circulating cell-free DNA profiling reveals ancestry-dependent genetic variation in metastatic prostate cancer.

Maleknia S et al.

Molecular Biomedicine, 2026

41673362 (PubMed )
Supplement: 43556_2026_405_MOESM3_ESM.xlsx › Common.Cosmic_Mut

Tumor-normal sequencing reveals novel TP53 germline and clinically actionable somatic mutations in Nigerian breast cancer patients.

Onyia AF et al.

Cancer Genetics, 2026

Somatic mutations in Middle East and North Africa breast cancer patients: a systematic review.

Abujamous L et al.

The Oncologist, 2025

40665690 (PubMed )
Supplement: oyaf205_supplementary_data.zip › SupplementaryTable3.xlsx › SupplementaryTable3

Mutational profiling using liquid biopsy to guide targeted therapy in patients with metastatic cancer.

Mazouji O et al.

Scientific Reports, 2025

40169620 (PubMed )
Supplement: 41598_2025_88094_MOESM1_ESM.xlsx › Feuil1

Comparison of targeted next generation sequencing assays in non-small cell lung cancer patients.

Drejeriene I et al.

Discover Oncology, 2024

Targeted sequencing for hereditary breast and ovarian cancer in BRCA1/2-negative families reveals complex genetic architecture and phenocopies.

Plowman JN et al.

Hgg Advances, 2024

38734904 (PubMed )
Supplement: mmc2.xlsx › Table_S5

Targeted next-generation sequencing of 491 lung cancers in clinical practice: Implications for future detection strategy and targeted therapy.

Liu XD et al.

Heliyon, 2024

38496837 (PubMed )
Supplement: mmc1.xlsx › Sheet1

Diagnostic Utility of Next-Generation Sequencing in Circulating Free DNA and a Comparison With Matched Tissue in Gallbladder Carcinoma.

Mishra S et al.

Laboratory Investigation; a Journal of Technical Methods and Pathology, 2024

Next-Generation DNA Sequencing of Grade 1 Meningioma Tumours: A Case Report of Angiomatous and Psammomatous Meningiomas.

Taher MM et al.

Cureus, 2024

The Prevalence of BRAF, PIK3CA, and RAS Mutations in Indian Patients with Colorectal Cancer.

Shetty O et al.

South Asian Journal of Cancer, 2022

Frequency of PIK3CA mutations in different subsites of head and neck squamous cell carcinoma in southern Thailand.

Dechaphunkul A et al.

Journal of Pathology and Translational Medicine, 2022

Mutations in TP53 and PIK3CA genes in hepatocellular carcinoma patients are associated with chronic Schistosomiasis.

AlGabbani Q

Saudi Journal of Biological Sciences, 2022

The Molecular Subtype of Adult Acute Lymphoblastic Leukemia Samples Determines the Engraftment Site and Proliferation Kinetics in Patient-Derived Xenograft Models.

Richter A et al.

Cells, 2022

Association of Pathway Mutations With Survival in Taiwanese Breast Cancers.

Yang PS et al.

Frontiers in Oncology, 2022

35936696 (PubMed )
Supplement: DataSheet_1.zip › Supplementary_Table_4.xlsx › ___2

Screening for PIK3CA mutations among Saudi women with ovarian cancer.

Al-Qahtani WS et al.

Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology, 2021

Spectrum of PIK3CA/AKT mutations across molecular subtypes of triple-negative breast cancer.

Kumar S et al.

Breast Cancer Research and Treatment, 2021

The Spectrum, Tendency and Predictive Value of PIK3CA Mutation in Chinese Colorectal Cancer Patients.

Fu X et al.

Frontiers in Oncology, 2021

PIK3CA H1047R Mutation Associated with a Lower Pathological Complete Response Rate in Triple-Negative Breast Cancer Patients Treated with Anthracycline-Taxane-Based Neoadjuvant Chemotherapy.

Guo S et al.

Cancer Research and Treatment, 2020

Defining an embryonal rhabdomyosarcoma endotype.

Ricker CA et al.

Cold Spring Harbor Molecular Case Studies, 2020

Efficacy of liquid-based genetic diagnosis of endometrial cancer.

Matsuura M et al.

Cancer Science, 2018

Targeted exome sequencing reveals distinct pathogenic variants in Iranians with colorectal cancer.

Ashktorab H et al.

Oncotarget, 2017

28002797 (PubMed )
Supplement: oncotarget-08-7852-s002.xlsx › PIK3CA.Ion

Impact of KRAS, BRAF, PIK3CA, TP53 status and intraindividual mutation heterogeneity on outcome after liver resection for colorectal cancer metastases.

Løes IM et al.

International Journal of Cancer, 2016

26991344 (PubMed )
Supplement: IJC-139-647-s003.xls › Suppl_Tbl_2

The diagnostic application of RNA sequencing in patients with thyroid cancer: an analysis of 851 variants and 133 fusions in 524 genes.

Pagan M et al.

Bmc Bioinformatics, 2016

26818556 (PubMed )
Supplement: 12859_2015_849_MOESM3_ESM.pdf

Novel mutations of PIK3CA gene in head and neck squamous cell carcinoma.

Al-Amri AM et al.

Cancer Biomarkers : Section a of Disease Markers, 2016

Identification of Variant-Specific Functions of PIK3CA by Rapid Phenotyping of Rare Mutations.

Dogruluk T et al.

Cancer Research, 2015

Genetic alterations of the PIK3CA oncogene in human oral squamous cell carcinoma in an Indian population.

Shah S et al.

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2015

A functional variant at miR-520a binding site in PIK3CA alters susceptibility to colorectal cancer in a Chinese Han population.

Ding L et al.

Biomed Research International, 2015

Genetic association between PIK3CA gene and oral squamous cell carcinoma: a case control study conducted in Chongqing, China.

Wan X et al.

International Journal of Clinical and Experimental Pathology, 2015

Prevalence of PIK3CA mutations and the SNP rs17849079 in Arab breast cancer patients.

Karakas B et al.

Cancer Biology & Therapy, 2013

Molecular changes in the phosphatidylinositide 3-kinase (PI3K) pathway are common in gastric cancer.

Tran TN et al.

Journal of Surgical Oncology, 2013

PIK3CA mutation, but not PTEN loss of function, determines the sensitivity of breast cancer cells to mTOR inhibitory drugs.

Weigelt B et al.

Oncogene, 2011

The structural impact of cancer-associated missense mutations in oncogenes and tumor suppressors.

Stehr H et al.

Molecular Cancer, 2011

21575214 (PubMed )
Supplement: 1476-4598-10-54-S3.XLS › mutations.txt

PI3K/Akt pathway mutations in retinoblastoma.

Cohen Y et al.

Investigative Ophthalmology & Visual Science, 2009

PIK3CA mutations in human solid tumors: role in sensitivity to various therapeutic approaches.

Ligresti G et al.

Cell Cycle (georgetown, Tex.), 2009

PIK3CA gene mutations and amplifications in uterine cancers, identified by methods that avoid confounding by PIK3CA pseudogene sequences.

Miyake T et al.

Cancer Letters, 2008

Mutations of the PIK3CA gene in hereditary colorectal cancers.

Miyaki M et al.

International Journal of Cancer, 2007

PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma.

Kozaki K et al.

Cancer Science, 2006

Mutational hotspot in exon 20 of PIK3CA in breast cancer among Singapore Chinese.

Liang X et al.

Cancer Biology & Therapy, 2006

Mutations of PIK3CA are rare in cutaneous melanoma.

Omholt K et al.

Melanoma Research, 2006

Mutation of the PIK3CA gene in anaplastic thyroid cancer.

García-Rostán G et al.

Cancer Research, 2005

Uncommon mutation, but common amplifications, of the PIK3CA gene in thyroid tumors.

Wu G et al.

The Journal of Clinical Endocrinology and Metabolism, 2005

Frequent mutation of the PIK3CA gene in ovarian and breast cancers.

Levine DA et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2005

PIK3CA mutations in advanced ovarian carcinomas.

Wang Y et al.

Human Mutation, 2005

Association of PIK3CA gene mutations with head and neck squamous cell carcinomas.

Kommineni N et al.

Neoplasma, 0

Germline and Somatic mutations in postmenopausal breast cancer patients.

Nagy TR et al.

Clinics (sao Paulo, Brazil), 0

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