Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

45 papers

NM_006218.4

p.T1025T

c.3075C>T

Surrounding Variants

1 paper

NM_006218.4

p.T1025T

c.3075C>A

1 paper

NM_006218.4

p.T1025_L1026insFs

c.3075_3076insT

1 paper

NM_006218.4

p.T1025T

c.3075C>G

15 papers

NM_006218.4

p.T1025N

c.3074C>A

1 paper

NM_006218.4

p.L1026I

c.3076C>A

1 paper

NM_006218.4

p.L1026fs

c.3076_3077fs

36 papers

NM_006218.4

p.T1025S

c.3074C>G

19 papers

NM_006218.4

p.T1025I

c.3074C>T

1 paper

NM_006218.4

p.L1026L

c.3076C>T

1 paper

NM_006218.4

p.T1025_L1026insTA

c.3073_3077ins6

1 paper

NM_006218.4

p.T1025P

c.3073A>C

139 papers

NM_006218.4

p.T1025A

c.3073A>G