Associated Papers
DDX39B drives colorectal cancer progression by promoting the stability and nuclear translocation of PKM2.
Zhao G et al.
Signal Transduction and Targeted Therapy, 2022
Translocalization of enhanced PKM2 protein into the nucleus induced by cancer upregulated gene 2 confers cancer stem cell-like phenotypes.
Yawut N et al.
Bmb Reports, 2022
Myeloid FBW7 deficiency disrupts redox homeostasis and aggravates dietary-induced insulin resistance.
Wang C et al.
Redox Biology, 2020
Cancer-associated mutations in human pyruvate kinase M2 impair enzyme activity.
Liu VM et al.
Febs Letters, 2020
Pyruvate kinase M2 regulates homologous recombination-mediated DNA double-strand break repair.
Sizemore ST et al.
Cell Research, 2018
30297868 (PubMed )
Supplement: 41422_2018_86_MOESM6_ESM.pdf
PARP Inhibition Suppresses Growth of EGFR-Mutant Cancers by Targeting Nuclear PKM2.
Li N et al.
Cell Reports, 2016
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.
Yang W et al.
Nature Cell Biology, 2012
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