Associated Papers
The S180R Human Germline Variant of DNA Polymerase β Is a Low Fidelity Enzyme with Reduced Flexibility of the Fingers Domain.
Sawyer DL et al.
Biochemistry, 2026
Single-molecule analysis of gap and nick binding by LIG1 and LIG3α at the final step of DNA repair.
Chatterjee S et al.
Biorxiv : the Preprint Server for Biology, 2025
Correct Nucleotide Selection Is Confined at the Binding Site of Polymerase Enzymes.
Figueroa Blanco DR et al.
Journal of Chemical Information and Modeling, 2024
SNP-Associated Substitutions of Amino Acid Residues in the dNTP Selection Subdomain Decrease Polβ Polymerase Activity.
Kladova OA et al.
Biomolecules, 2024
Unfilled gaps by polβ lead to aberrant ligation by LIG1 at the downstream steps of base excision repair pathway.
Gulkis M et al.
Nucleic Acids Research, 2024
Melanoma-derived DNA polymerase theta variants exhibit altered DNA polymerase activity.
Thomas C et al.
Biorxiv : the Preprint Server for Biology, 2023
The Role of Natural Polymorphic Variants of DNA Polymerase β in DNA Repair.
Kladova OA et al.
International Journal of Molecular Sciences, 2022
Defective DNA polymerase beta invoke a cytosolic DNA mediated inflammatory response.
Zhao S et al.
Frontiers in Immunology, 2022
DNA Polymerase β in the Context of Cancer.
Sawyer DL et al.
Critical Reviews in Oncogenesis, 2022
Revealing an Internal Stabilization Deficiency in the DNA Polymerase β K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography.
Batra VK et al.
Biochemistry, 2020
The Pol β variant containing exon α is deficient in DNA polymerase but has full dRP lyase activity.
Dai DP et al.
Scientific Reports, 2019
Detection of Somatic Mutation in Exon 12 of DNA Polymerase β in Ovarian Cancer Tissue Samples
Khanra K et al.
Iranian Biomedical Journal, 2018
DNA Polymerase Beta Germline Variant Confers Cellular Response to Cisplatin Therapy.
Nemec AA et al.
Molecular Cancer Research : Mcr, 2017
R152C DNA Pol β mutation impairs base excision repair and induces cellular transformation.
Zhou T et al.
Oncotarget, 2016
HeLa Cells Containing a Truncated Form of DNA Polymerase Beta are More Sensitized to Alkylating Agents than to Agents Inducing Oxidative Stress.
Khanra K et al.
Asian Pacific Journal of Cancer Prevention : Apjcp, 2015
Substrate-induced DNA polymerase β activation.
Beard WA et al.
The Journal of Biological Chemistry, 2014
The S229L colon tumor-associated variant of DNA polymerase β induces cellular transformation as a result of decreased polymerization efficiency.
Nemec AA et al.
The Journal of Biological Chemistry, 2014
Substrate rescue of DNA polymerase β containing a catastrophic L22P mutation.
Kirby TW et al.
Biochemistry, 2014
Cellular roles of DNA polymerase beta.
Ray S et al.
The Yale Journal of Biology and Medicine, 2013
The E295K cancer variant of human polymerase β favors the mismatch conformational pathway during nucleotide selection.
Eckenroth BE et al.
The Journal of Biological Chemistry, 2013
Structural changes in the hydrophobic hinge region adversely affect the activity and fidelity of the I260Q mutator DNA polymerase β.
Gridley CL et al.
Biochemistry, 2013
DNA polymerase β variant Ile260Met generates global gene expression changes related to cellular transformation.
Donigan KA et al.
Mutagenesis, 2012
[Mechanism of DNA polymerase beta hyper-expression in malignant transformation induced by benzo[a] pyrene].
Zhao W et al.
Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition, 2012
Colon cancer-associated DNA polymerase β variant induces genomic instability and cellular transformation.
Nemec AA et al.
The Journal of Biological Chemistry, 2012
Human POLB gene is mutated in high percentage of colorectal tumors.
Donigan KA et al.
The Journal of Biological Chemistry, 2012
The E288K colon tumor variant of DNA polymerase β is a sequence specific mutator.
Murphy DL et al.
Biochemistry, 2012
Unfavorable electrostatic and steric interactions in DNA polymerase β E295K mutant interfere with the enzyme's pathway.
Li Y et al.
Journal of the American Chemical Society, 2012
Deregulated expression of DNA polymerase β is involved in the progression of genomic instability.
Luo Q et al.
Environmental and Molecular Mutagenesis, 2012
The human gastric cancer-associated DNA polymerase β variant D160N is a mutator that induces cellular transformation.
Donigan KA et al.
Dna Repair, 2012
Metal-induced DNA translocation leads to DNA polymerase conformational activation.
Kirby TW et al.
Nucleic Acids Research, 2012
Association of two polymorphisms of DNA polymerase beta in exon-9 and exon-11 with ovarian carcinoma in India.
Khanra K et al.
Asian Pacific Journal of Cancer Prevention : Apjcp, 2012
Association of a newly identified variant of DNA polymerase beta (polβΔ63-123, 208-304) with the risk factor of ovarian carcinoma in India.
Khanra K et al.
Asian Pacific Journal of Cancer Prevention : Apjcp, 2012
A germline polymorphism of DNA polymerase beta induces genomic instability and cellular transformation.
Yamtich J et al.
Plos Genetics, 2012
Genome instability caused by a germline mutation in the human DNA repair gene POLB.
Sobol RW
Plos Genetics, 2012
Systematic biochemical analysis of somatic missense mutations in DNA polymerase β found in prostate cancer reveal alteration of enzymatic function.
An CL et al.
Human Mutation, 2011
Targeted radiosensitization of cells expressing truncated DNA polymerase {beta}.
Neijenhuis S et al.
Cancer Research, 2010
A cancer-associated DNA polymerase delta variant modeled in yeast causes a catastrophic increase in genomic instability.
Daee DL et al.
Proceedings of the National Academy of Sciences of the United States of America, 2010
Potentiation of temozolomide cytotoxicity by inhibition of DNA polymerase beta is accentuated by BRCA2 mutation.
Stachelek GC et al.
Cancer Research, 2010
Characterization of DNA polymerase beta splicing variants in gastric cancer: the most frequent exon 2-deleted isoform is a non-coding RNA.
Simonelli V et al.
Mutation Research, 2009
The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient.
Dalal S et al.
Nucleic Acids Research, 2008
The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation.
Lang T et al.
Molecular and Cellular Biology, 2007