Associated Papers
RAF1 kinase contributes to autophagic lysosome reformation.
Toifl S et al.
Cell Reports, 2025
Characterization of MEK1/2 Degraders Uncovers a Kinase-Independent Role for MEK1/2 in the Stabilization and Maturation of CRAF.
Wasserman JS et al.
Biorxiv : the Preprint Server for Biology, 2025
Wild-type C-Raf gene dosage and dimerization drive prostate cancer metastasis.
Ta L et al.
Iscience, 2023
KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation.
Tran TH et al.
Nature Communications, 2021
Metabolic stress regulates ERK activity by controlling KSR-RAF heterodimerization.
Verlande A et al.
Embo Reports, 2018
Kinase-independent role for CRAF-driving tumour radioresistance via CHK2.
Advani SJ et al.
Nature Communications, 2015
MEK-1 activates C-Raf through a Ras-independent mechanism.
Leicht DT et al.
Biochimica Et Biophysica Acta, 2013
A MEK-independent role for CRAF in mitosis and tumor progression.
Mielgo A et al.
Nature Medicine, 2011
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.
Johannessen CM et al.
Nature, 2010
C-Raf inhibits MAPK activation and transformation by B-Raf(V600E).
Karreth FA et al.
Molecular Cell, 2009
The C-terminus of Raf-1 acts as a 14-3-3-dependent activation switch.
Dhillon AS et al.
Cellular Signalling, 2009
Characterization of Ser338 phosphorylation for Raf-1 activation.
Zang M et al.
The Journal of Biological Chemistry, 2008
Raf-1 and B-Raf promote protein kinase C theta interaction with BAD.
Hindley A et al.
Cellular Signalling, 2007
Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway.
Wilbanks AM et al.
Science (new York, N.y.), 2004
Erythropoietin regulation of Raf-1 and MEK: evidence for a Ras-independent mechanism.
Chen C et al.
Blood, 2004
Functional analysis of a phosphatidic acid binding domain in human Raf-1 kinase: mutations in the phosphatidate binding domain lead to tail and trunk abnormalities in developing zebrafish embryos.
Ghosh S et al.
The Journal of Biological Chemistry, 2003
Identification of residues and domains of Raf important for function in vivo and in vitro.
Harding A et al.
The Journal of Biological Chemistry, 2003
Regulation of Raf through phosphorylation and N terminus-C terminus interaction.
Chong H et al.
The Journal of Biological Chemistry, 2003
Phosphorylation of 338SSYY341 regulates specific interaction between Raf-1 and MEK1.
Xiang X et al.
The Journal of Biological Chemistry, 2002
The role of Hsp90N, a new member of the Hsp90 family, in signal transduction and neoplastic transformation.
Grammatikakis N et al.
The Journal of Biological Chemistry, 2002
Phosphorylation of the myosin-binding subunit of myosin phosphatase by Raf-1 and inhibition of phosphatase activity.
Broustas CG et al.
The Journal of Biological Chemistry, 2002
Microtubule integrity regulates Pak leading to Ras-independent activation of Raf-1. insights into mechanisms of Raf-1 activation.
Zang M et al.
The Journal of Biological Chemistry, 2001
The Src signaling pathway regulates osteoclast lysosomal enzyme secretion and is rapidly modulated by estrogen.
Pascoe D et al.
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 2001
Kinase suppressor of Ras signals through Thr269 of c-Raf-1.
Xing HR et al.
The Journal of Biological Chemistry, 2001
The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
Rizzo MA et al.
The Journal of Biological Chemistry, 2000
The ankyrin repeat-containing adaptor protein Tvl-1 is a novel substrate and regulator of Raf-1.
Lin JH et al.
The Journal of Biological Chemistry, 1999
Characterization of Raf-1 activation in mitosis.
Laird AD et al.
The Journal of Biological Chemistry, 1999
Distinct mechanisms mediate the initial and sustained phases of integrin-mediated activation of the Raf/MEK/mitogen-activated protein kinase cascade.
Howe AK et al.
The Journal of Biological Chemistry, 1998
Mammalian Raf-1 is activated by mutations that restore Raf signaling in Drosophila.
Cutler RE et al.
The Embo Journal, 1997
Regulation of Raf-1 and Raf-1 mutants by Ras-dependent and Ras-independent mechanisms in vitro.
Dent P et al.
Molecular and Cellular Biology, 1995