Varaico: Literature-Extracted Genetic Variants

RAF1

1,521 papers

RefSeq Summary

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to w...

Pfam Domains

RBDaa 57–131UCSCRaf-like Ras-binding domain

C1_1aa 139–187UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 349–606UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

Raf-1 proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

Raf-1; c-Raf; CRAF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

30 papers

NM_002880.4

p.K375M

c.1124A>T

Surrounding Variants

1 paper

NM_002880.4

p.K375R

c.1124A>G

1 paper

NM_002880.4

p.K375N

c.1125G>T

1 paper

NM_002880.4

p.K375N

c.1125G>C

1 paper

NM_002880.4

p.K375K

c.1125G>A

2 papers

NM_002880.4

p.K375E

c.1123A>G

1 paper

NM_002880.4

p.I376L

c.1126A>C

1 paper

NM_002880.4

p.V380I

c.1138G>A

1 paper

NM_002880.4

p.D381_P382insATC

c.1141_1145ins9

2 papers

NM_002880.4

p.D381N

c.1141G>A

1 paper

NM_002880.4

p.D381D

c.1143C>T

1 paper

NM_002880.4

p.T383A

c.1147A>G

1 paper

NM_002880.4

p.T383N

c.1148C>A