Associated Papers
Inactivation of Sirt6 ameliorates muscular dystrophy in mdx mice by releasing suppression of utrophin expression.
Georgieva AM et al.
Nature Communications, 2022
Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.
Wang H et al.
Scientific Reports, 2021
SIRT6 transcriptionally regulates fatty acid transport by suppressing PPARγ.
Khan D et al.
Cell Reports, 2021
Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.
Li X et al.
Npj Precision Oncology, 2021
An ordered assembly of MYH glycosylase, SIRT6 protein deacetylase, and Rad9-Rad1-Hus1 checkpoint clamp at oxidatively damaged telomeres.
Tan J et al.
Aging, 2020
The deacetylase SIRT6 promotes the repair of UV-induced DNA damage by targeting DDB2.
Geng A et al.
Nucleic Acids Research, 2020
Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice.
Meng F et al.
Elife, 2020
SIRT6 coordinates with CHD4 to promote chromatin relaxation and DNA repair.
Hou T et al.
Nucleic Acids Research, 2020
Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in mice.
Maity S et al.
The Journal of Biological Chemistry, 2020
Histone H3 Lysine 56 Acetylation Enhances AP Endonuclease 1-Mediated Repair of AP Sites in Nucleosome Core Particles.
Rodriguez Y et al.
Biochemistry, 2019
SIRT6 deficiency results in developmental retardation in cynomolgus monkeys.
Zhang W et al.
Nature, 2018
BRCA1 function in the intra-S checkpoint is activated by acetylation via a pCAF/SIRT1 axis.
Lahusen TJ et al.
Oncogene, 2018
SIRT6 facilitates directional telomere movement upon oxidative damage.
Gao Y et al.
Scientific Reports, 2018
Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice.
Ghosh S et al.
Elife, 2018
Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells' vulnerability to DNA-damaging agents.
Cagnetta A et al.
Haematologica, 2018
SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation.
Zhang X et al.
Elife, 2017
SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence.
Tasselli L et al.
Nature Structural & Molecular Biology, 2016
SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2.
Pan H et al.
Cell Research, 2016
Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair.
Ghosh S et al.
Cell Reports, 2015
Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer.
Kugel S et al.
Cell Reports, 2015
A proteomic perspective of Sirtuin 6 (SIRT6) phosphorylation and interactions and their dependence on its catalytic activity.
Miteva YV et al.
Molecular & Cellular Proteomics : Mcp, 2014
SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine.
Jiang H et al.
Nature, 2013
Functional dissection of SIRT6: identification of domains that regulate histone deacetylase activity and chromatin localization.
Tennen RI et al.
Mechanisms of Ageing and Development, 2010
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin.
Michishita E et al.
Nature, 2008