Varaico: Literature-Extracted Genetic Variants

Gene:SIRT6
Variant:p.H133Y

SIRT6

142 papers

RefSeq Summary

This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is loc...

Pfam Domains

SIR2aa 78–221UCSCSir2 family
SIR2aa 78–221UCSCSir2 family
SIR2aa 78–221UCSCSir2 family

Gene Aliases

HGNC Name

sirtuin 6

HGNC Previous Names

sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6; sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
25 papers
NM_016539.4
p.H133Y
c.397C>T
Surrounding Variants
1 paper
NM_016539.4
p.G134W
c.400G>T
1 paper
NM_016539.4
p.R150*
c.448C>T
1 paper
NM_016539.4
p.A161T
c.481G>A
1 paper
NM_016539.4
p.A169P
c.505G>C
1 paper
NM_016539.4
p.V168delFs
c.504delC
1 paper
NM_016539.4
p.L174L
c.520C>T
1 paper
NM_016539.4
p.A176V
c.527C>T
1 paper
NM_016539.4
p.L181L
c.541C>T
1 paper
NM_016539.4
p.L197P
c.590T>C
1 paper
NM_016539.4
p.E202*
c.604G>T
1 paper
NM_016539.4
p.R205Splc
c.615-8G>A
1 paper
NM_016539.4
p.G214C
c.640G>T
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