Associated Papers
Evaluating predictors of kinase activity of STK11 variants identified in primary human non-small cell lung cancers.
Chen Y et al.
Human Genetics, 2025
Evaluating predictors of kinase activity of STK11 variants identified in primary human non-small cell lung cancers.
Chen Y et al.
Research Square, 2024
The Utility of NGS Analysis in Homologous Recombination Deficiency Tracking.
Tsantikidi A et al.
Diagnostics (basel, Switzerland), 2023
Targeted Next-Generation Sequencing-Based Multiple Gene Mutation Profiling of Patients with Rectal Adenocarcinoma Receiving or Not Receiving Neoadjuvant Chemoradiotherapy.
Chang YK et al.
International Journal of Molecular Sciences, 2022
CDKN2A loss-of-function predicts immunotherapy resistance in non-small cell lung cancer.
Gutiontov SI et al.
Scientific Reports, 2021
Systematic analysis of the intersection of disease mutations with protein modifications.
Simpson CM et al.
Bmc Medical Genomics, 2019
Clinical manifestations and STK11 germline mutations in Taiwanese patients with Peutz-Jeghers syndrome.
Chiang JM et al.
Asian Journal of Surgery, 2018
Controlling the master-upstream regulation of the tumor suppressor LKB1.
Kullmann L et al.
Oncogene, 2018
LKB1 Tumor Suppressor: Therapeutic Opportunities Knock when LKB1 Is Inactivated.
Zhou W et al.
Genes & Diseases, 2014
High Resolution Melting analysis as a rapid and efficient method of screening for small mutations in the STK11 gene in patients with Peutz-Jeghers syndrome.
Borun P et al.
Bmc Medical Genetics, 2013
Molecular chaperone complexes with antagonizing activities regulate stability and activity of the tumor suppressor LKB1.
Gaude H et al.
Oncogene, 2012
PhenoHM: human-mouse comparative phenome-genome server.
Sardana D et al.
Nucleic Acids Research, 2010
A novel mutation of STK11/LKB1 gene leads to the loss of cell growth inhibition in head and neck squamous cell carcinoma.
Qiu W et al.
Oncogene, 2006
LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes.
Mehenni H et al.
Human Molecular Genetics, 2005
Stability of the Peutz-Jeghers syndrome kinase LKB1 requires its binding to the molecular chaperones Hsp90/Cdc37.
Nony P et al.
Oncogene, 2003
Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome.
Lim W et al.
British Journal of Cancer, 2003
LKB1, a protein kinase regulating cell proliferation and polarity.
Boudeau J et al.
Febs Letters, 2003
Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1).
Tiainen M et al.
Human Molecular Genetics, 2002
5'-CpG island methylation of the LKB1/STK11 promoter and allelic loss at chromosome 19p13.3 in sporadic colorectal cancer.
Trojan J et al.
Gut, 2000
LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo.
Collins SP et al.
The Biochemical Journal, 2000
Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest.
Tiainen M et al.
Proceedings of the National Academy of Sciences of the United States of America, 1999
Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer.
Ylikorkala A et al.
Human Molecular Genetics, 1999
Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity.
Mehenni H et al.
American Journal of Human Genetics, 1998