Associated Papers
TDP-43 in neurodegeneration and cancer: Decoding the mechanism of mRNA localization and translation.
Pang P et al.
Biochemistry and Biophysics Reports, 2026
TDP-43 pathology is linked to motor neuron loss but is independent of stress granules in vivo.
Dubinski A et al.
Biorxiv : the Preprint Server for Biology, 2026
Golgi fragmentation driven by the USP11-ITCH axis triggers autolysosomal failure in neurodegeneration.
Xiang Q et al.
Autophagy, 2026
Mutant TDP-43 drives impairments in axonal transport and glycolysis in a mouse stem-cell-derived motor neuron model of amyotrophic lateral sclerosis (ALS).
Carroll E et al.
Cell Death & Disease, 2026
From Dish to Trial: Building Translational Models of ALS.
Salamotas I et al.
Cells, 2026
From Evasion to Collapse: The Kinetic Cascade of TDP-43 and the Failure of Proteostasis.
Jamerlan A et al.
International Journal of Molecular Sciences, 2026
Computational Exploration of the Molecular Mechanism of Epigallocatechin Gallate against TDP-43 Aggregation.
Yi W et al.
Journal of Chemical Information and Modeling, 2026
Inhibiting Glycogen Synthase Kinase 3 Suppresses TDP-43-Mediated Neurotoxicity in a Caspase-Dependent Manner.
White MA et al.
Molecular Neurobiology, 2026
Molecular Mechanisms and Therapeutic Potential of Degron-Mediated Proteostasis Regulation in Neurodegenerative Diseases.
Nishanth DS et al.
Cellular and Molecular Neurobiology, 2026
Calcineurin depletion coincides with phosphorylated TDP-43 deposition in a mouse model of ALS/FTLD-TDP.
Waldherr SM et al.
Acta Neuropathologica Communications, 2026
TARDBP (TDP-43) Knock-in Zebrafish Display a Late-Onset Motor Phenotype and Loss of Large Spinal Cord Motor Neurons.
Harji ZA et al.
Annals of Neurology, 2026
Neurodegenerative disease and autophagy in iPSC-based models.
Odonchimed S et al.
Neuroscience Research, 2026
Alleviation of mutant TDP-43-mediated neuropathology by inducible stem cells in monkeys.
Song X et al.
International Journal of Biological Sciences, 2026
G-Quadruplexes Abet Neuronal Burnout in ALS and FTD.
Herbert A
Antioxidants (basel, Switzerland), 2025
Site-specific methionine oxidation alters structure and phase separation of TDP-43 C-terminal domain.
Ozguney B et al.
Biorxiv : the Preprint Server for Biology, 2025
TDP-43 dysfunction compromises UPF1-dependent mRNA metabolism in ALS.
Alessandrini F et al.
Neuron, 2025
Revisiting oligodendrocytes in amyotrophic lateral sclerosis using human multicellular stem cell models.
Mouhi S et al.
Trends in Cell Biology, 2025
Ubiquitination in the Nervous System: From Molecular Mechanisms to Disease Implications.
Xue Y et al.
Molecular Neurobiology, 2025
CRISPR/Cas9 a genomic engineering technology for treatment in ALS mouse models.
Khan H et al.
Regenerative Therapy, 2025
Structural details of helix-mediated multimerization of the conserved region of TDP-43 C-terminal domain.
Rizuan A et al.
Nature Communications, 2025
MARK2 regulates C9orf72 repeat-associated non-AUG translation.
Lu YN et al.
Proceedings of the National Academy of Sciences of the United States of America, 2025
Co-localization of tau and TDP-43 after extracellular vesicle delivery to cells.
Aliakbari F et al.
The Febs Journal, 2025
In-Depth Study of Low-Complexity Domains: From Structural Diversity to Disease Mechanisms.
Xu H et al.
Cells, 2025
On the potential roles of TDP-43 in the formation of membraneless organelles and their transformation into toxic aggregates.
Sergeeva OS et al.
Biochemical and Biophysical Research Communications, 2025
Histone Post-Translational Modifications and DNA Double-Strand Break Repair in Neurodegenerative Diseases: An Epigenetic Perspective.
Yeasmin A et al.
Biology, 2025
The mechanisms underlying TDP-43-associated neurodegeneration in Alzheimer's disease and related dementias.
Gao J et al.
Molecular Psychiatry, 2025
TRAF6 regulates ubiquitination-independent TDP-43 condensation and related neurodegeneration.
Guo S et al.
Molecular Psychiatry, 2025
C9orf72 ALS-causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules.
Bilican S et al.
Febs Letters, 2025
Schwann cells as a therapeutic target for amyotrophic lateral sclerosis: A TDP-43 focussed review.
Lewis KN et al.
Neurochemistry International, 2025
Muscle-derived miR-126 regulates TDP-43 axonal local synthesis and NMJ integrity in ALS models.
Ionescu A et al.
Nature Neuroscience, 2025
TDP-43 in Alzheimer's disease: Pathophysiology and therapeutic strategies.
Zhou X et al.
Pharmacological Research, 2025
TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes.
Zeng Y et al.
Nature Neuroscience, 2025
ITCH regulates Golgi integrity and proteotoxicity in neurodegeneration.
Xiang Q et al.
Science Advances, 2025
A next-generation HDAC6 inhibitor for amyotrophic lateral sclerosis and frontotemporal dementia.
James RE et al.
Brain : a Journal of Neurology, 2025
RNA helicase maheshvara interacts with TDP-43 and exacerbates neurodegeneration in Drosophila model of amyotrophic lateral sclerosis.
Pandey P et al.
Neurobiology of Disease, 2025
Pathological forms of TDP-43 in amyotrophic lateral sclerosis (ALS) promote aberrant telomere elongation.
Konopka A et al.
Biochimica Et Biophysica Acta. Molecular Basis of Disease, 2025
Genetic architecture of amyotrophic lateral sclerosis: a comprehensive review.
Yuan L et al.
Journal of Genetics and Genomics = Yi Chuan Xue Bao, 2025
Two Families With Amyotrophic Lateral Sclerosis Founder Mutation TARDBP p.G298S in Hong Kong.
Yip MK et al.
Cureus, 2025
MYC-driven gliosis impairs neuron-glia communication in amyotrophic lateral sclerosis.
Fioretti PV et al.
Brain : a Journal of Neurology, 2025
In vivo self-assembled siRNAs ameliorate neurological pathology in TDP-43-associated neurodegenerative disease.
Wu J et al.
Brain : a Journal of Neurology, 2025
Nemo-like kinase disrupts nuclear import and drives TDP43 mislocalization in ALS.
Bekier ME et al.
The Journal of Clinical Investigation, 2025
A cellular model of TDP-43 induces phosphorylated TDP-43 aggregation with distinct changes in solubility and autophagy dysregulation.
Dopler MB et al.
The Febs Journal, 2025
Cryptic Splicing of GAP43 mRNA is a Novel Hallmark of TDP-43-Associated ALS and AD.
Yang M et al.
Advanced Science (weinheim, Baden-wurttemberg, Germany), 2025
The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation.
Koyuncu S et al.
Nature Aging, 2025