Varaico: Literature-Extracted Genetic Variants

Gene:TET2
Variant:p.R1896S
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TET2

NM_001127208.3:p.R1896S

Associated Papers

Mutation of Epigenetic Regulators at Diagnosis Is an Independent Predictor of Tyrosine Kinase Inhibitor Treatment Failure in Chronic Myeloid Leukemia: A Report From the RESIDIAG Study.

Guerineau H et al.

American Journal of Hematology, 2025

39654506 (PubMed )
Supplement: supplement_1.pdf

Human HDAC6 senses valine abundancy to regulate DNA damage.

Jin J et al.

Nature, 2025

Poor Applicability of Currently Available Prognostic Scoring Systems for Prediction of Outcome in KIT D816V-Negative Advanced Systemic Mastocytosis.

Naumann N et al.

Cancers, 2024

TET2 is required to suppress mTORC1 signaling through urea cycle with therapeutic potential.

He J et al.

Cell Discovery, 2023

TET2 Suppresses VHL Deficiency-Driven Clear Cell Renal Cell Carcinoma by Inhibiting HIF Signaling.

Zhang X et al.

Cancer Research, 2022

Tumor suppressor TET2 promotes cancer immunity and immunotherapy efficacy.

Xu YP et al.

The Journal of Clinical Investigation, 2019

Convenient expression, purification and quantitative liquid chromatography-tandem mass spectrometry-based analysis of TET2 5-methylcytosine demethylase.

Jaiswal M et al.

Protein Expression and Purification, 2017

Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes.

Laukka T et al.

The Journal of Biological Chemistry, 2016

Evaluation of allelic strength of human TET2 mutations and cooperation between Tet2 knockdown and oncogenic Nras mutation.

Chang YI et al.

British Journal of Haematology, 2014

Feature-based classification of amino acid substitutions outside conserved functional protein domains.

Gemovic B et al.

Thescientificworldjournal, 2013

24348198 (PubMed )
Supplement: 948617.f1.pdf

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2.

Ko M et al.

Nature, 2010

Acquired mutations in TET2 are common in myelodysplastic syndromes.

Langemeijer SM et al.

Nature Genetics, 2009

Targeted next-generation sequencing-based sequencing of cell-free DNA in cerebrospinal fluid uncovers cancer-specific mutations in patients with brain cancer using a widely available panel.

Köpp A et al.

Neuro-oncology Advances, 0

41664825 (PubMed )
Supplement: vdaf270_supplementary_data.zip › Table_S2.xlsx › Variants_Blood_and_CSF
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