Associated Papers
TP53 variant clusters stratify phenotypic diversity in germline carriers and reveal an osteosarcoma-prone subgroup.
Fischer NW et al.
Nature Communications, 2025
p53 SUMOylation promotes neurogenesis defects in APP/PS1 mice.
Yin A et al.
Journal of Alzheimer's Disease : Jad, 2025
Age-related p53 SUMOylation accelerates senescence and tau pathology in Alzheimer's disease.
Wan L et al.
Cell Death and Differentiation, 2025
Structural and mechanistic diversity in p53-mediated regulation of organismal longevity across taxonomical orders.
Osbourne R et al.
Biorxiv : the Preprint Server for Biology, 2024
Simplified algorithm for genetic subtyping in diffuse large B-cell lymphoma.
Shen R et al.
Signal Transduction and Targeted Therapy, 2023
Tumor Suppressor p53 Down-Regulates Programmed Cell Death Protein 4 (PDCD4) Expression.
Yang WH et al.
Current Oncology (toronto, Ont.), 2023
TP53_PROF: a machine learning model to predict impact of missense mutations in TP53.
Ben-Cohen G et al.
Briefings in Bioinformatics, 2022
Pathogenic genetic variants from highly connected cancer susceptibility genes confer the loss of structural stability.
Reza MN et al.
Scientific Reports, 2021
Dysfunction of X-linked inhibitor of apoptosis protein (XIAP) triggers neuropathological processes via altered p53 activity in Huntington's disease.
Hyeon SJ et al.
Progress in Neurobiology, 2021
Targeted sequencing of FH-deficient uterine leiomyomas reveals biallelic inactivating somatic fumarase variants and allows characterization of missense variants.
Popp B et al.
Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 2020
Glycogen synthase kinase (GSK)-3 and the double-strand RNA-dependent kinase, PKR: When two kinases for the common good turn bad.
Piazzi M et al.
Biochimica Et Biophysica Acta. Molecular Cell Research, 2020
Heterochromatin protects retinal pigment epithelium cells from oxidative damage by silencing p53 target genes.
Gong L et al.
Proceedings of the National Academy of Sciences of the United States of America, 2018
Inhibiting p53 Acetylation Reduces Cancer Chemotoxicity.
Zheng S et al.
Cancer Research, 2017
The p53 C terminus controls site-specific DNA binding and promotes structural changes within the central DNA binding domain.
Laptenko O et al.
Molecular Cell, 2015
The nucleolar protein Myb-binding protein 1A (MYBBP1A) enhances p53 tetramerization and acetylation in response to nucleolar disruption.
Ono W et al.
The Journal of Biological Chemistry, 2014
PIASxα ligase enhances SUMO1 modification of PTEN protein as a SUMO E3 ligase.
Wang W et al.
The Journal of Biological Chemistry, 2014
p53 SUMOylation promotes its nuclear export by facilitating its release from the nuclear export receptor CRM1.
Santiago A et al.
Molecular Biology of the Cell, 2013
PIASy-mediated Tip60 sumoylation regulates p53-induced autophagy.
Naidu SR et al.
Cell Cycle (georgetown, Tex.), 2012
The RAX/PACT-PKR stress response pathway promotes p53 sumoylation and activation, leading to G₁ arrest.
Bennett RL et al.
Cell Cycle (georgetown, Tex.), 2012
PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation.
Heo KS et al.
The Journal of Cell Biology, 2011
p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase.
Jiang P et al.
Nature Cell Biology, 2011
Small ubiquitin-related modifier paralogs are indispensable but functionally redundant during early development of zebrafish.
Yuan H et al.
Cell Research, 2010
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
Wu SY et al.
The Embo Journal, 2009
How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?
Olsson A et al.
Cell Death and Differentiation, 2007
SUMO-specific protease SUSP4 positively regulates p53 by promoting Mdm2 self-ubiquitination.
Lee MH et al.
Nature Cell Biology, 2006
An intact sequence-specific DNA-binding domain is required for human cytomegalovirus-mediated sequestration of p53 and may promote in vivo binding to the viral genome during infection.
Rosenke K et al.
Virology, 2006
Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity.
Xirodimas DP et al.
Cell, 2004
Functional analysis and intracellular localization of p53 modified by SUMO-1.
Kwek SS et al.
Oncogene, 2001
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
Fogal V et al.
The Embo Journal, 2000
c-Jun and p53 activity is modulated by SUMO-1 modification.
Muller S et al.
The Journal of Biological Chemistry, 2000
SUMO-1 modification activates the transcriptional response of p53.
Rodriguez MS et al.
The Embo Journal, 1999
Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.
Gostissa M et al.
The Embo Journal, 1999