Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

32 papers

NM_000546.6

p.K386R

c.1157A>G

Surrounding Variants

3 papers

NM_000546.6

p.K386M

c.1157A>T

3 papers

NM_000546.6

p.K386T

c.1157A>C

1 paper

NM_000546.6

p.M384_F385del2

c.1150_1154del6

6 papers

NM_000546.6

p.K386N

c.1158G>T

6 papers

NM_000546.6

p.K386N

c.1158G>C

3 papers

NM_000546.6

p.K386E

c.1156A>G

5 papers

NM_000546.6

p.K386Q

c.1156A>C

1 paper

NM_000546.6

p.K386_T387insT

c.1156_1160ins3

3 papers

NM_000546.6

p.F385delFs

c.1155delG

1 paper

NM_000546.6

p.F385F

c.1155C>T

8 papers

NM_000546.6

p.F385L

c.1155C>G

1 paper

NM_000546.6

p.F385insFs

c.1154dupT