Associated Papers
The p53 R181C mutation accumulates through impaired deacetylation by Sirt1 and facilitates tumor development.
Wang E et al.
Communications Biology, 2026
Acetylation promotes mutant (MUT) TP53-HSPA8 and HSPA8-BAG3 interactions, facilitating MUT TP53 lysosomal degradation preferentially via CASA.
Di Crosta M et al.
Autophagy, 2025
TP53 variant clusters stratify phenotypic diversity in germline carriers and reveal an osteosarcoma-prone subgroup.
Fischer NW et al.
Nature Communications, 2025
Cabozantinib selectively induces proteasomal degradation of p53 somatic mutant Y220C and impedes tumor growth.
Lv FL et al.
The Journal of Biological Chemistry, 2025
Structural and mechanistic diversity in p53-mediated regulation of organismal longevity across taxonomical orders.
Osbourne R et al.
Biorxiv : the Preprint Server for Biology, 2024
The complexity of p53-mediated metabolic regulation in tumor suppression.
Liu Y et al.
Seminars in Cancer Biology, 2022
Vitamin C-induced competitive binding of HIF-1α and p53 to ubiquitin E3 ligase CBL contributes to anti-breast cancer progression through p53 deacetylation.
Xiong Y et al.
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 2022
Cancer-derived C-terminus-extended p53 mutation confers dominant-negative effect on its wild-type counterpart.
Huang S et al.
Journal of Molecular Cell Biology, 2022
TP53_PROF: a machine learning model to predict impact of missense mutations in TP53.
Ben-Cohen G et al.
Briefings in Bioinformatics, 2022
Analysis of single-nucleotide polymorphisms in genes associated with triple-negative breast cancer.
G V et al.
Frontiers in Genetics, 2022
TIRR inhibits the 53BP1-p53 complex to alter cell-fate programs.
Parnandi N et al.
Molecular Cell, 2021
mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression.
Kon N et al.
Genes & Development, 2021
Insights into the limitations of transient expression systems for the functional study of p53 acetylation site and oncogenic mutants.
Bruer M et al.
Biochemical and Biophysical Research Communications, 2020
PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth.
Cai W et al.
Nature Communications, 2019
Temporal and differential regulation of KAISO-controlled transcription by phosphorylated and acetylated p53 highlights a crucial regulatory role of apoptosis.
Choi SH et al.
The Journal of Biological Chemistry, 2019
Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity.
Loffreda A et al.
Nature Communications, 2017
Inhibiting p53 Acetylation Reduces Cancer Chemotoxicity.
Zheng S et al.
Cancer Research, 2017
Synergy between histone deacetylase inhibitors and DNA-damaging agents is mediated by histone deacetylase 2 in colorectal cancer.
Alzoubi S et al.
Oncotarget, 2016
The p53 C terminus controls site-specific DNA binding and promotes structural changes within the central DNA binding domain.
Laptenko O et al.
Molecular Cell, 2015
Modulation of homology-directed repair in T98G glioblastoma cells due to interactions between wildtype p53, Rad51 and HCMV IE1-72.
Kulkarni AS et al.
Viruses, 2014
Novel histone deacetylase inhibitor CG200745 induces clonogenic cell death by modulating acetylation of p53 in cancer cells.
Oh ET et al.
Investigational New Drugs, 2012
p53 requires an intact C-terminal domain for DNA binding and transactivation.
Kim H et al.
Journal of Molecular Biology, 2012
p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200.
Morselli E et al.
Cell Cycle (georgetown, Tex.), 2011
Nox1 is involved in p53 deacetylation and suppression of its transcriptional activity and apoptosis.
Puca R et al.
Free Radical Biology & Medicine, 2010
HIPK2 modulates p53 activity towards pro-apoptotic transcription.
Puca R et al.
Molecular Cancer, 2009
p53 acetylation is crucial for its transcription-independent proapoptotic functions.
Yamaguchi H et al.
The Journal of Biological Chemistry, 2009
Monocytic leukemia zinc finger (MOZ) interacts with p53 to induce p21 expression and cell-cycle arrest.
Rokudai S et al.
The Journal of Biological Chemistry, 2009
An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21Waf1/Cip1 in response to 5-aza-2'-deoxycytidine treatment.
Wang H et al.
The Journal of Biological Chemistry, 2008
An acetylation switch in p53 mediates holo-TFIID recruitment.
Li AG et al.
Molecular Cell, 2007
p53 stabilization and transactivation by a von Hippel-Lindau protein.
Roe JS et al.
Molecular Cell, 2006
An intact sequence-specific DNA-binding domain is required for human cytomegalovirus-mediated sequestration of p53 and may promote in vivo binding to the viral genome during infection.
Rosenke K et al.
Virology, 2006
Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1).
Zhao Y et al.
Molecular and Cellular Biology, 2006
HIPK2 contributes to PCAF-mediated p53 acetylation and selective transactivation of p21Waf1 after nonapoptotic DNA damage.
Di Stefano V et al.
Oncogene, 2005
Negative regulation of p53 functions by Daxx and the involvement of MDM2.
Zhao LY et al.
The Journal of Biological Chemistry, 2004
Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity.
Xirodimas DP et al.
Cell, 2004
PML regulates p53 stability by sequestering Mdm2 to the nucleolus.
Bernardi R et al.
Nature Cell Biology, 2004
Impairment of p53 acetylation, stability and function by an oncogenic transcription factor.
Insinga A et al.
The Embo Journal, 2004
Regulation of p53 stability and function in HCT116 colon cancer cells.
Kaeser MD et al.
The Journal of Biological Chemistry, 2004
Identification and characterization of a novel p300-mediated p53 acetylation site, lysine 305.
Wang YH et al.
The Journal of Biological Chemistry, 2003
Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2.
Hofmann TG et al.
Nature Cell Biology, 2002
Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases.
Barlev NA et al.
Molecular Cell, 2001
PML regulates p53 acetylation and premature senescence induced by oncogenic Ras.
Pearson M et al.
Nature, 2000