Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

43 papers

NM_000546.6

p.K382R

c.1145A>G

Surrounding Variants

3 papers

NM_000546.6

p.K382I

c.1145A>T

4 papers

NM_000546.6

p.K382T

c.1145A>C

2 papers

NM_000546.6

p.K382N

c.1146A>T

1 paper

NM_000546.6

p.K382*

c.1144A>T

4 papers

NM_000546.6

p.K382E

c.1144A>G

1 paper

NM_000546.6

p.K382K

c.1146A>G

16 papers

NM_000546.6

p.K382Q

c.1144A>C

2 papers

NM_000546.6

p.K382N

c.1146A>C

28 papers

NM_000546.6

p.K382fs

c.1144_1145fs

1 paper

NM_000546.6

p.K382_L383insT

c.1144_1148ins3

1 paper

NM_000546.6

p.K382_L383ins12

c.1144_1148ins36

1 paper

NM_000546.6

p.H380_K381insFs

c.1139_1142dup4