Associated Papers
Dominant-Negative Effects of p53 R337 Variants in Li-Fraumeni Syndrome: Impact on Tetramer Formation and Transcriptional Activity.
Kamada R et al.
Chembiochem : a European Journal of Chemical Biology, 2025
Myelodysplastic neoplasms with ring sideroblasts without SF3B1 mutations in adults: enrichment of germline variants in congenital sideroblastic anemia genes.
Novoa-Jáuregui S et al.
Leukemia, 2025
Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations.
Funk JS et al.
Nature Genetics, 2025
Comprehensive classification of TP53 somatic missense variants based on their impact on p53 structural stability.
Tam B et al.
Briefings in Bioinformatics, 2024
TP53 germline pathogenic variants in modern humans were likely originated during recent human history.
Kou SH et al.
Nar Cancer, 2023
Water Leakage Pathway Leads to Internal Hydration of the p53 Core Domain.
Lima IDM et al.
Biochemistry, 2023
Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog.
Zhang Q et al.
Cell Death & Disease, 2022
Analysis and Interpretation of the Impact of Missense Variants in Cancer.
Petrosino M et al.
International Journal of Molecular Sciences, 2021
The disordered DNA-binding domain of p53 is indispensable for forming an encounter complex to and jumping along DNA.
Graha Subekti DR et al.
Biochemical and Biophysical Research Communications, 2021
Liquid-like droplet formation by tumor suppressor p53 induced by multivalent electrostatic interactions between two disordered domains.
Kamagata K et al.
Scientific Reports, 2020
Incidence and distribution of UroSEEK gene panel in a multi-institutional cohort of bladder urothelial carcinoma.
Eich ML et al.
Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 2019
Finding driver mutations in cancer: Elucidating the role of background mutational processes.
Brown AL et al.
Plos Computational Biology, 2019
The Disordered Linker in p53 Participates in Nonspecific Binding to and One-Dimensional Sliding along DNA Revealed by Single-Molecule Fluorescence Measurements.
Subekti DRG et al.
Biochemistry, 2017
Reactivation of mutant p53: Constraints on mechanism highlighted by principal component analysis of the DNA binding domain.
Ouaray Z et al.
Proteins, 2016
Isolation, characterization and functional analysis of full length p53 cDNA from Bubalus bubalis.
Singh M et al.
Gene, 2015
Oxidation of p53 through DNA charge transport involves a network of disulfides within the DNA-binding domain.
Schaefer KN et al.
Biochemistry, 2015
mCSM: predicting the effects of mutations in proteins using graph-based signatures.
Pires DE et al.
Bioinformatics (oxford, England), 2014
Effects of stability on the biological function of p53.
Khoo KH et al.
The Journal of Biological Chemistry, 2009
Adaptive evolution of p53 thermodynamic stability.
Khoo KH et al.
Journal of Molecular Biology, 2009
Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core.
Khoo KH et al.
Protein Engineering, Design & Selection : Peds, 2009
Stability of the core domain of p53: insights from computer simulations.
Madhumalar A et al.
Bmc Bioinformatics, 2008
Structure-function-rescue: the diverse nature of common p53 cancer mutants.
Joerger AC et al.
Oncogene, 2007
Structural assessment of single amino acid mutations: application to TP53 function.
Yip YL et al.
Human Mutation, 2006