Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

23 papers

NM_000546.6

p.Y236F

c.707A>T

Surrounding Variants

286 papers

NM_000546.6

p.Y236C

c.707A>G

32 papers

NM_000546.6

p.Y236S

c.707A>C

1 paper

NM_000546.6

p.N235_Y236delFs

c.705_706delAG

1 paper

NM_000546.6

p.I232_Y236delFs

c.696_706del11

1 paper

NM_000546.6

p.Y236_M237insAC

c.706_710ins6

74 papers

NM_000546.6

p.Y236D

c.706T>G

68 papers

NM_000546.6

p.Y236H

c.706T>C

50 papers

NM_000546.6

p.Y236N

c.706T>A

3 papers

NM_000546.6

p.N235delFs

c.705delG

2 papers

NM_000546.6

p.N235del1

c.703_705delGTT

1 paper

NM_000546.6

p.H233_N235delFs

c.699_705del7

1 paper

NM_000546.6

p.I232_N235delFs

c.696_705del10