Varaico: Literature-Extracted Genetic Variants

AGO2

334 papers

RefSeq Summary

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact ...

Pfam Domains

ArgoNaa 36–166UCSCN-terminal domain of argonaute

ArgoL1aa 176–226UCSCArgonaute linker 1 domain

PAZaa 238–365UCSCPAZ domain

ArgoL2aa 374–420UCSCArgonaute linker 2 domain

ArgoMidaa 429–511UCSCMid domain of argonaute

Piwiaa 517–818UCSCPiwi domain

Gene Aliases

HGNC Name

argonaute RISC catalytic component 2

HGNC Previous Symbols

EIF2C2; CASC7

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

13 papers

NM_012154.5

p.D669A

c.2006A>C

Surrounding Variants

1 paper

NM_012154.5

p.E673A

c.2018A>C

1 paper

NM_012154.5

p.R663C

c.1987C>T

1 paper

NM_012154.5

p.R663_I664insTT

c.1987_1991ins6

1 paper

NM_012154.5

p.F676L

c.2026T>C

1 paper

NM_012154.5

p.F676L

c.2028C>G

1 paper

NM_012154.5

p.F676L

c.2028C>A

1 paper

NM_012154.5

p.P661H

c.1982C>A

1 paper

NM_012154.5

p.F659L

c.1977C>G

1 paper

NM_012154.5

p.R658G

c.1972C>G

1 paper

NM_012154.5

p.T657A

c.1969A>G

1 paper

NM_012154.5

p.K655R

c.1964A>G

1 paper

NM_012154.5

p.A643insFs

c.1928_1929insA