Varaico: Literature-Extracted Genetic Variants

AGO2

334 papers

RefSeq Summary

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact ...

Pfam Domains

ArgoNaa 36–166UCSCN-terminal domain of argonaute

ArgoL1aa 176–226UCSCArgonaute linker 1 domain

PAZaa 238–365UCSCPAZ domain

ArgoL2aa 374–420UCSCArgonaute linker 2 domain

ArgoMidaa 429–511UCSCMid domain of argonaute

Piwiaa 517–818UCSCPiwi domain

Gene Aliases

HGNC Name

argonaute RISC catalytic component 2

HGNC Previous Symbols

EIF2C2; CASC7

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_012154.5

p.A603fs

c.1807_1808fs

Surrounding Variants

1 paper

NM_012154.5

p.P602insFs

c.1806dupC

2 papers

NM_012154.5

p.P602delFs

c.1806delG

2 papers

NM_012154.5

p.P602R

c.1805C>G

2 papers

NM_012154.5

p.A603fs

c.1807_1808fs

1 paper

NM_012154.5

p.G604R

c.1810G>C

1 paper

NM_012154.5

p.G604R

c.1810G>A

2 papers

NM_012154.5

p.G604_D605insFs

c.1812_1813insG

1 paper

NM_012154.5

p.H600Y

c.1798C>T

1 paper

NM_012154.5

p.V598I

c.1792G>A

12 papers

NM_012154.5

p.D597A

c.1790A>C

1 paper

NM_012154.5

p.I592M

c.1776C>G

1 paper

NM_012154.5

p.R583R

c.1749G>A