Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

1–12 of 3373 variants

15057 papers

NM_004333.6

p.V600E

c.1799T>A

952 papers

NM_004333.6

p.K601E

c.1801A>G

696 papers

NM_004333.6

p.G469A

c.1406G>C

653 papers

NM_004333.6

p.V157I

c.469G>A

537 papers

NM_004333.6

p.D594G

c.1781A>G

415 papers

NM_004333.6

p.D594N

c.1780G>A

375 papers

NM_004333.6

p.G466V

c.1397G>T

312 papers

NM_004333.6

p.G469V

c.1406G>T

311 papers

NM_004333.6

p.V600M

c.1798G>A

280 papers

NM_004333.6

p.G466E

c.1397G>A

279 papers

NM_004333.6

p.N581S

c.1742A>G

259 papers

NM_004333.6

p.G469E

c.1406G>A