Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

15057 papers

NM_004333.6

p.V600E

c.1799T>A

NM_001374258.1

p.V640E

c.1919T>A

Surrounding Variants

1 paper

NM_004333.6

p.V600ins1

c.1799_1800insCTT

1 paper

NM_004333.6

p.V600insFs

c.1798dupG

2 papers

NM_004333.6

p.D594_V600ins2

c.1781_1798dup18

185 papers

NM_004333.6

p.V600G

c.1799T>G

1 paper

NM_004333.6

p.V600Fs

c.1799delinsAGFs

1 paper

NM_004333.6

p.V600Fs

c.1799delinsATTTTGGTCTAGCTACAGFs

100 papers

NM_004333.6

p.V600A

c.1799T>C

4 papers

NM_004333.6

p.V600Fs

c.1799delinsAAFs

3 papers

NM_004333.6

p.V600delins

c.1798_1799delinsCG

46 papers

NM_004333.6

p.V600delins

c.1798_1799delinsAG

1 paper

NM_004333.6

p.V600delins

c.1798_1799delinsCA

91 papers

NM_004333.6

p.V600delins

c.1798_1799delinsAA