Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

279 papers

NM_004333.6

p.N581S

c.1742A>G

Surrounding Variants

132 papers

NM_004333.6

p.N581I

c.1742A>T

37 papers

NM_004333.6

p.N581T

c.1742A>C

18 papers

NM_004333.6

p.N581K

c.1743T>G

18 papers

NM_004333.6

p.N581K

c.1743T>A

1 paper

NM_004333.6

p.N581delFs

c.1742delT

36 papers

NM_004333.6

p.N581Y

c.1741A>T

53 papers

NM_004333.6

p.N581D

c.1741A>G

18 papers

NM_004333.6

p.N581H

c.1741A>C

1 paper

NM_004333.6

p.I582L

c.1744A>T

2 papers

NM_004333.6

p.I582V

c.1744A>G

1 paper

NM_004333.6

p.I582L

c.1744A>C

1 paper

NM_004333.6

p.I582K

c.1745T>A