Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004333.6

p.T546S

c.1636A>T

Surrounding Variants

7 papers

NM_004333.6

p.E545D

c.1635G>T

7 papers

NM_004333.6

p.E545D

c.1635G>C

1 paper

NM_004333.6

p.T546S

c.1637C>G

1 paper

NM_004333.6

p.T546N

c.1637C>A

1 paper

NM_004333.6

p.E545V

c.1634A>T

25 papers

NM_004333.6

p.E545G

c.1634A>G

26 papers

NM_004333.6

p.E545A

c.1634A>C

2 papers

NM_004333.6

p.E545*

c.1633G>T

15 papers

NM_004333.6

p.E545Q

c.1633G>C

152 papers

NM_004333.6

p.E545K

c.1633G>A

1 paper

NM_004333.6

p.I544I

c.1632T>C

1 paper

NM_004333.6

p.K547I

c.1640A>T