Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004333.6

p.G466G

c.1398A>G

Surrounding Variants

1 paper

NM_004333.6

p.G466fs

c.1396_1397fs

35 papers

NM_004333.6

p.S467A

c.1399T>G

1 paper

NM_004333.6

p.S467P

c.1399T>C

375 papers

NM_004333.6

p.G466V

c.1397G>T

164 papers

NM_004333.6

p.G466A

c.1397G>C

280 papers

NM_004333.6

p.G466E

c.1397G>A

1 paper

NM_004333.6

p.G466delins

c.1396_1397delinsTT

5 papers

NM_004333.6

p.G466*

c.1396G>T

128 papers

NM_004333.6

p.G466R

c.1396G>C

132 papers

NM_004333.6

p.G466R

c.1396G>A

83 papers

NM_004333.6

p.S467L

c.1400C>T

1 paper

NM_004333.6

p.S467*

c.1400C>G