Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_004333.6

p.V459A

c.1376T>C

Surrounding Variants

21 papers

NM_004333.6

p.V459L

c.1375G>T

1 paper

NM_001378473.1

p.V407insFs

c.1219_1220insC

1 paper

NM_004333.6

p.V459_G460ins9

c.1375_1379ins27

22 papers

NM_004333.6

p.V459L

c.1375G>C

2 papers

NM_004333.6

p.V459M

c.1375G>A

1 paper

NM_004333.6

p.V459delFs

c.1376delA

4 papers

NM_004333.6

p.G460R

c.1378G>C

4 papers

NM_004333.6

p.G460R

c.1378G>A

3 papers

NM_004333.6

p.G460E

c.1379G>A

7 papers

NM_004333.6

p.G460G

c.1380A>G

1 paper

NM_004333.6

p.T458A

c.1372A>G

1 paper

NM_001378473.1

p.G408G

c.1224A>C