Varaico: Literature-Extracted Genetic Variants

Gene:CASP3
Variant:p.V189insFs

CASP3

926 papers

RefSeq Summary

The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) p...

Pfam Domains

Peptidase_C14aa 44–274UCSCCaspase domain

Gene Aliases

HGNC Name

caspase 3

HGNC Alias Symbols

CPP32; CPP32B; Yama; apopain

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_004346.4
p.V189insFs
c.566_567insA
Surrounding Variants
1 paper
NM_004346.4
p.V189M
c.565G>A
1 paper
NM_004346.4
p.E190*
c.568G>T
1 paper
NM_004346.4
p.E190A
c.569A>C
1 paper
NM_004346.4
p.A191G
c.572C>G
1 paper
NM_004346.4
p.K186R
c.557A>G
1 paper
NM_004346.4
p.F193L
c.577T>C
1 paper
NM_004346.4
p.H185Q
c.555T>A
1 paper
NM_004346.4
p.F193L
c.579C>G
1 paper
NM_004346.4
p.F193L
c.579C>A
4 papers
NM_004346.4
p.L194F
c.582G>T
4 papers
NM_004346.4
p.L194F
c.582G>C
1 paper
NM_004346.4
p.Y195_A196insT
c.583_587ins3
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."