Varaico: Literature-Extracted Genetic Variants

EIF2AK2

344 papers

RefSeq Summary

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate trans...

Pfam Domains

dsrmaa 10–75UCSCDouble-stranded RNA binding motif

dsrmaa 101–165UCSCDouble-stranded RNA binding motif

Pkinaseaa 267–537UCSCProtein kinase domain

Gene Aliases

HGNC Name

eukaryotic translation initiation factor 2 alpha kinase 2

HGNC Previous Symbol

PRKR

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001135651.3

p.R445*

c.1333C>T

Surrounding Variants

4 papers

NM_001135651.3

p.T446A

c.1336A>G

1 paper

NM_001135651.3

p.K449*

c.1345A>T

1 paper

NM_001135651.3

p.S448_K449insFs

c.1344_1345insT

1 paper

NM_001135651.3

p.L439V

c.1315C>G

4 papers

NM_001135651.3

p.T451A

c.1351A>G

2 papers

NM_001135651.3

p.L452S

c.1355T>C

1 paper

NM_001135651.3

p.R453*

c.1357C>T

1 paper

NM_001135651.3

p.D432A

c.1295A>C

1 paper

NM_001135651.3

p.I430V

c.1288A>G

1 paper

NM_001135651.3

p.K429R

c.1286A>G

1 paper

NM_001135651.3

p.V428E

c.1283T>A

1 paper

NM_001135651.3

p.T425I

c.1274C>T