Varaico: Literature-Extracted Genetic Variants

EIF2AK2

344 papers

RefSeq Summary

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate trans...

Pfam Domains

dsrmaa 10–75UCSCDouble-stranded RNA binding motif

dsrmaa 101–165UCSCDouble-stranded RNA binding motif

Pkinaseaa 267–537UCSCProtein kinase domain

Gene Aliases

HGNC Name

eukaryotic translation initiation factor 2 alpha kinase 2

HGNC Previous Symbol

PRKR

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001135651.3

p.D266A

c.797A>C

Surrounding Variants

1 paper

NM_001135651.3

p.D266Y

c.796G>T

1 paper

NM_001135651.3

p.F267_K268insFs

c.801_802insTT

1 paper

NM_001135651.3

p.I270_E271delFs

c.810_813del4

1 paper

NM_001135651.3

p.A284T

c.850G>A

1 paper

NM_001135651.3

p.R287_I288delFs

c.861_862delTT

1 paper

NM_001135651.3

p.D289A

c.866A>C

1 paper

NM_001135651.3

p.G290A

c.869G>C

1 paper

NM_001135651.3

p.V294I

c.880G>A

28 papers

NM_001135651.3

p.K296R

c.887A>G

1 paper

NM_001135651.3

p.R262Splc

c.786-96C>T

1 paper

NM_001135651.3

p.E303Splc

c.908+1G>A

2 papers

NM_001135651.3

p.E303K

c.907G>A