Varaico: Literature-Extracted Genetic Variants

FLT3

2,401 papers

RefSeq Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, whic...

Pfam Domains

igaa 258–343UCSCImmunoglobulin domain

PK_Tyr_Ser-Thraa 610–943UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 3

HGNC Alias Symbols

FLK2; CD135

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_004119.3

p.S840Y

c.2519C>A

Surrounding Variants

7 papers

NM_004119.3

p.S840_N841ins2

c.2520_2521ins6

8 papers

NM_004119.3

p.D839E

c.2517T>G

8 papers

NM_004119.3

p.D839E

c.2517T>A

12 papers

NM_004119.3

p.N841Y

c.2521A>T

1 paper

NM_004119.3

p.N841D

c.2521A>G

5 papers

NM_004119.3

p.N841H

c.2521A>C

1 paper

NM_004119.3

p.N841ins2

c.2521_2522ins6

82 papers

NM_004119.3

p.N841I

c.2522A>T

78 papers

NM_004119.3

p.D839G

c.2516A>G

1 paper

NM_004119.3

p.N841S

c.2522A>G

17 papers

NM_004119.3

p.N841T

c.2522A>C

6 papers

NM_004119.3

p.D839A

c.2516A>C