Varaico: Literature-Extracted Genetic Variants

FLT3

2,401 papers

RefSeq Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, whic...

Pfam Domains

igaa 258–343UCSCImmunoglobulin domain

PK_Tyr_Ser-Thraa 610–943UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 3

HGNC Alias Symbols

FLK2; CD135

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

5 papers

NM_004119.3

p.I836V

c.2506A>G

Surrounding Variants

1 paper

NM_004119.3

p.I836fs

c.2506_2507fs

4 papers

NM_004119.3

p.I836F

c.2506A>T

9 papers

NM_004119.3

p.I836L

c.2506A>C

26 papers

NM_004119.3

p.D835del1

c.2503_2505delATC

3 papers

NM_004119.3

p.R834_D835del0

c.2500_2505del6

2 papers

NM_004119.3

p.I836ins1

c.2507_2508insGCC

176 papers

NM_004119.3

p.D835E

c.2505T>G

4 papers

NM_004119.3

p.I836S

c.2507T>G

7 papers

NM_004119.3

p.I836T

c.2507T>C

175 papers

NM_004119.3

p.D835E

c.2505T>A

3 papers

NM_004119.3

p.I836N

c.2507T>A

1 paper

NM_004119.3

p.I836I

c.2508C>T