Varaico: Literature-Extracted Genetic Variants

FLT3

2,401 papers

RefSeq Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, whic...

Pfam Domains

igaa 258–343UCSCImmunoglobulin domain

PK_Tyr_Ser-Thraa 610–943UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 3

HGNC Alias Symbols

FLK2; CD135

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

11 papers

NM_004119.3

p.Y591F

c.1772A>T

Surrounding Variants

7 papers

NM_004119.3

p.Y591C

c.1772A>G

1 paper

NM_004119.3

p.Y591S

c.1772A>C

1 paper

NM_004119.3

p.Y591ins3

c.1771_1772ins9

1 paper

NM_004119.3

p.Y589_F590del1

c.1767_1769delAAG

1 paper

NM_004119.3

p.Y591ins3

c.1771_1772ins9

1 paper

NM_004119.3

p.F590insFs

c.1769_1770ins19

2 papers

NM_004119.3

p.F590_Y591insFs

c.1770_1771insCC

1 paper

NM_004119.3

p.F590_Y591ins2

c.1770_1771ins6

1 paper

NM_004119.3

p.Y591ins8

c.1771_1772ins24

13 papers

NM_004119.3

p.Y591D

c.1771T>G

4 papers

NM_004119.3

p.Y591H

c.1771T>C

2 papers

NM_004119.3

p.Y591N

c.1771T>A