Varaico: Literature-Extracted Genetic Variants

FLT3

2,401 papers

RefSeq Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, whic...

Pfam Domains

igaa 258–343UCSCImmunoglobulin domain

PK_Tyr_Ser-Thraa 610–943UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 3

HGNC Alias Symbols

FLK2; CD135

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004119.3

p.Q575E

c.1723C>G

Surrounding Variants

1 paper

NM_004119.3

p.Q575*

c.1723C>T

1 paper

NM_004119.3

p.Q575L

c.1724A>T

1 paper

NM_004119.3

p.Q575R

c.1724A>G

8 papers

NM_004119.3

p.Q575P

c.1724A>C

2 papers

NM_004119.3

p.S574N

c.1721G>A

1 paper

NM_004119.3

p.S574delFs

c.1720delT

1 paper

NM_004119.3

p.E573_Q575delFs

c.1718_1724del7

1 paper

NM_004119.3

p.L576I

c.1726C>A

7 papers

NM_004119.3

p.S574G

c.1720A>G

1 paper

NM_004119.3

p.E573ins0

c.1717_1719dupGAA

10 papers

NM_004119.3

p.L576R

c.1727T>G

25 papers

NM_004119.3

p.L576P

c.1727T>C