Varaico: Literature-Extracted Genetic Variants

FLT3

2,401 papers

RefSeq Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, whic...

Pfam Domains

igaa 258–343UCSCImmunoglobulin domain

PK_Tyr_Ser-Thraa 610–943UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 3

HGNC Alias Symbols

FLK2; CD135

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

47 papers

NM_004119.3

p.Y572C

c.1715A>G

Surrounding Variants

2 papers

NM_004119.3

p.Y572F

c.1715A>T

3 papers

NM_004119.3

p.Y572S

c.1715A>C

1 paper

NM_004119.3

p.Y572ins2

c.1715_1716ins6

1 paper

NM_004119.3

p.Y572_E573insFs

c.1716_1717insG

1 paper

NM_004119.3

p.Y572H

c.1714T>C

2 papers

NM_004119.3

p.E573K

c.1717G>A

2 papers

NM_004119.3

p.Q569_R571delFs

c.1705_1712del8

1 paper

NM_004119.3

p.E573fs

c.1717_1718fs

7 papers

NM_004119.3

p.E573G

c.1718A>G

5 papers

NM_004119.3

p.E573D

c.1719A>T

1 paper

NM_004119.3

p.R571W

c.1711A>T

5 papers

NM_004119.3

p.E573D

c.1719A>C