Varaico: Literature-Extracted Genetic Variants

GRK2

235 papers

RefSeq Summary

This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates incl...

Pfam Domains

RGSaa 54–174UCSCRegulator of G protein signaling domain

Pkinaseaa 191–453UCSCProtein kinase domain

PHaa 559–652UCSCPH domain

Gene Aliases

HGNC Name

G protein-coupled receptor kinase 2

HGNC Previous Symbol

ADRBK1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_001619.5

p.K220M

c.659A>T

Surrounding Variants

48 papers

NM_001619.5

p.K220R

c.659A>G

1 paper

NM_001619.5

p.R226C

c.676C>T

1 paper

NM_001619.5

p.K228E

c.682A>G

1 paper

NM_001619.5

p.K230R

c.689A>G

1 paper

NM_001619.5

p.N238D

c.712A>G

1 paper

NM_001619.5

p.R240H

c.719G>A

1 paper

NM_001619.5

p.V246I

c.736G>A

1 paper

NM_001619.5

p.V246F

c.736G>T

1 paper

NM_001619.5

p.P252A

c.754C>G

1 paper

NM_001619.5

p.S268T

c.803G>C

1 paper

NM_001619.5

p.M216Splc

c.647+1G>A

1 paper

NM_001619.5

p.C208S

c.623G>C