Varaico: Literature-Extracted Genetic Variants

GRK2

235 papers

RefSeq Summary

This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates incl...

Pfam Domains

RGSaa 54–174UCSCRegulator of G protein signaling domain

Pkinaseaa 191–453UCSCProtein kinase domain

PHaa 559–652UCSCPH domain

Gene Aliases

HGNC Name

G protein-coupled receptor kinase 2

HGNC Previous Symbol

ADRBK1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

5 papers

NM_001619.5

p.D527A

c.1580A>C

Surrounding Variants

1 paper

NM_001619.5

p.T528A

c.1582A>G

1 paper

NM_001619.5

p.V525A

c.1574T>C

1 paper

NM_001619.5

p.N530S

c.1589A>G

1 paper

NM_001619.5

p.E523A

c.1568A>C

2 papers

NM_001619.5

p.E532A

c.1595A>C

2 papers

NM_001619.5

p.E520A

c.1559A>C

1 paper

NM_001619.5

p.R516W

c.1546C>T

1 paper

NM_001619.5

p.E515fs

c.1543_1544fs

2 papers

NM_001619.5

p.G495A

c.1484G>C

2 papers

NM_001619.5

p.E490K

c.1468G>A

2 papers

NM_001619.5

p.D484A

c.1451A>C

3 papers

NM_001619.5

p.D481A

c.1442A>C