Varaico: Literature-Extracted Genetic Variants

Gene:GRK4
Variant:p.L133R

GRK4

160 papers

RefSeq Summary

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms ...

Pfam Domains

RGSaa 52–171UCSCRegulator of G protein signaling domain
Pkinaseaa 187–449UCSCProtein kinase domain

Gene Aliases

HGNC Name

G protein-coupled receptor kinase 4

HGNC Previous Symbol

GPRK2L

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_182982.3
p.L133R
c.398T>G
Surrounding Variants
1 paper
NM_182982.3
p.L133L
c.397C>T
1 paper
NM_182982.3
p.K134Q
c.400A>C
1 paper
NM_182982.3
p.E135insFs
c.404_405insT
1 paper
NM_182982.3
p.C129S
c.386G>C
1 paper
NM_182982.3
p.C129F
c.386G>T
1 paper
NM_182982.3
p.C129S
c.385T>A
1 paper
NM_182982.3
p.S139C
c.416C>G
1 paper
NM_182982.3
p.A142fs
c.424_425fs
53 papers
NM_182982.3
p.A142V
c.425C>T
1 paper
NM_182982.3
p.F143Y
c.428T>A
7 papers
NM_182982.3
p.A116T
c.346G>A
1 paper
NM_182982.3
p.R148Splc
c.443+8G>C
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."