Varaico: Literature-Extracted Genetic Variants

GRM2

124 papers

RefSeq Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in mo...

Pfam Domains

ANF_receptoraa 60–460UCSCReceptor family ligand binding region

NCD3Gaa 495–546UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 561–813UCSC7 transmembrane sweet-taste receptor of 3 GCPR

Gene Aliases

HGNC Name

glutamate metabotropic receptor 2

HGNC Alias Symbols

GPRC1B; mGlu2; MGLUR2

Papers

RefSeq ID

Protein change

DNA change

1–12 of 145 variants

6 papers

NM_000839.5

p.H41N

c.121C>A

3 papers

NM_000839.5

p.I315V

c.943A>G

3 papers

NM_000839.5

p.N439S

c.1316A>G

3 papers

NM_000839.5

p.S688L

c.2063C>T

3 papers

NM_000839.5

p.G689V

c.2066G>T

3 papers

NM_000839.5

p.F756S

c.2267T>C

2 papers

NM_000839.5

p.L12P

c.35T>C

2 papers

NM_000839.5

p.R255*

c.763C>T

2 papers

NM_000839.5

p.D295A

c.884A>C

2 papers

NM_000839.5

p.R346H

c.1037G>A

2 papers

NM_000839.5

p.A497T

c.1489G>A

2 papers

NM_000839.5

p.S601A

c.1801T>G