Varaico: Literature-Extracted Genetic Variants

GRM2

124 papers

RefSeq Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in mo...

Pfam Domains

ANF_receptoraa 60–460UCSCReceptor family ligand binding region

NCD3Gaa 495–546UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 561–813UCSC7 transmembrane sweet-taste receptor of 3 GCPR

Gene Aliases

HGNC Name

glutamate metabotropic receptor 2

HGNC Alias Symbols

GPRC1B; mGlu2; MGLUR2

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000839.5

p.G689V

c.2066G>T

Surrounding Variants

3 papers

NM_000839.5

p.S688L

c.2063C>T

1 paper

NM_000839.5

p.L692F

c.2074C>T

2 papers

NM_000839.5

p.A685G

c.2054C>G

2 papers

NM_000839.5

p.A677S

c.2029G>T

1 paper

NM_000839.5

p.G706S

c.2116G>A

1 paper

NM_000839.5

p.R672C

c.2014C>T

2 papers

NM_000839.5

p.R670W

c.2008C>T

1 paper

NM_000839.5

p.A710A

c.2130C>T

1 paper

NM_000839.5

p.P711A

c.2131C>G

1 paper

NM_000839.5

p.G667S

c.1999G>A

1 paper

NM_000839.5

p.E712K

c.2134G>A

1 paper

NM_000839.5

p.E666A

c.1997A>C