Varaico: Literature-Extracted Genetic Variants

Gene:IRAK1
Variant:p.R133W

IRAK1

294 papers

RefSeq Summary

This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene...

Pfam Domains

Deathaa 27–103UCSCDeath domain
Pkinaseaa 212–517UCSCProtein kinase domain

Gene Aliases

HGNC Name

interleukin 1 receptor associated kinase 1

HGNC Alias Symbol

pelle

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
5 papers
NM_001569.4
p.R133W
c.397C>T
Surrounding Variants
1 paper
NM_001569.4
p.R133fs
c.397_398fs
4 papers
NM_001569.4
p.K134R
c.401A>G
1 paper
NM_001569.4
p.W130G
c.388T>G
1 paper
NM_001569.4
p.A139P
c.415G>C
1 paper
NM_001569.4
p.A139V
c.416C>T
1 paper
NM_001569.4
p.E126K
c.376G>A
1 paper
NM_001569.4
p.T141A
c.421A>G
1 paper
NM_001569.4
p.T141T
c.423C>A
1 paper
NM_001569.4
p.S144A
c.430T>G
5 papers
NM_001569.4
p.S120C
c.358A>T
1 paper
NM_001569.4
p.T114T
c.342T>A
1 paper
NM_001569.4
p.T114A
c.340A>G
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."