Varaico: Literature-Extracted Genetic Variants

LATS1

253 papers

RefSeq Summary

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is pho...

Pfam Domains

UBAaa 101–138UCSCUBA/TS-N domain

Pkinaseaa 705–866UCSCProtein kinase domain

Pkinaseaa 896–1010UCSCProtein kinase domain

Pkinase_Caa 1030–1080UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

large tumor suppressor kinase 1

HGNC Alias Symbol

WARTS

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004690.4

p.L849H

c.2546T>A

Surrounding Variants

1 paper

NM_004690.4

p.T851A

c.2551A>G

5 papers

NM_004690.4

p.T851I

c.2552C>T

4 papers

NM_004690.4

p.D846A

c.2537A>C

1 paper

NM_004690.4

p.R854T

c.2561G>C

2 papers

NM_004690.4

p.R854K

c.2561G>A

1 paper

NM_004690.4

p.L844M

c.2530T>A

1 paper

NM_004690.4

p.I842T

c.2525T>C

2 papers

NM_004690.4

p.H841Y

c.2521C>T

1 paper

NM_004690.4

p.G840V

c.2519G>T

1 paper

NM_004690.4

p.R838H

c.2513G>A

1 paper

NM_004690.4

p.K860R

c.2579A>G

1 paper

NM_004690.4

p.R838fs

c.2512_2513fs