Varaico: Literature-Extracted Genetic Variants

LCK

326 papers

RefSeq Summary

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-termina...

Pfam Domains

SH3_1aa 67–113UCSCSH3 domain

SH2aa 127–209UCSCSH2 domain

PK_Tyr_Ser-Thraa 245–494UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

LCK proto-oncogene, Src family tyrosine kinase

HGNC Previous Name

lymphocyte-specific protein tyrosine kinase

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005356.5

p.G34R

c.100G>C

Surrounding Variants

1 paper

NM_005356.5

p.G34G

c.102C>T

1 paper

NM_005356.5

p.K33E

c.97A>G

1 paper

NM_005356.5

p.L30M

c.88C>A

1 paper

NM_005356.5

p.T35_L36Splc

c.105+9C>T

3 papers

NM_005356.5

p.V28L

c.82G>C

1 paper

NM_005356.5

p.V28del1

c.82_83delGTC

4 papers

NM_005356.5

p.P26R

c.77C>G

1 paper

NM_005356.5

p.C23Fs

c.67delinsGTFs

1 paper

NM_005356.5

p.C20W

c.60T>G

1 paper

NM_005356.5

p.D18N

c.52G>A

2 papers

NM_005356.5

p.I17T

c.50T>C

1 paper

NM_005356.5

p.I17V

c.49A>G