Varaico: Literature-Extracted Genetic Variants

LCK

326 papers

RefSeq Summary

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-termina...

Pfam Domains

SH3_1aa 67–113UCSCSH3 domain

SH2aa 127–209UCSCSH2 domain

PK_Tyr_Ser-Thraa 245–494UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

LCK proto-oncogene, Src family tyrosine kinase

HGNC Previous Name

lymphocyte-specific protein tyrosine kinase

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_005356.5

p.K273E

c.817A>G

Surrounding Variants

3 papers

NM_005356.5

p.K273R

c.818A>G

2 papers

NM_005356.5

p.A271V

c.812C>T

1 paper

NM_005356.5

p.V270L

c.808G>T

1 paper

NM_005356.5

p.K276R

c.827A>G

1 paper

NM_005356.5

p.T268T

c.804G>A

1 paper

NM_005356.5

p.G278D

c.833G>A

1 paper

NM_005356.5

p.H267P

c.800A>C

1 paper

NM_005356.5

p.D283V

c.848A>T

1 paper

NM_005356.5

p.D283D

c.849C>T

1 paper

NM_005356.5

p.A284S

c.850G>T

2 papers

NM_005356.5

p.A284G

c.851C>G

1 paper

NM_005356.5

p.A284V

c.851C>T