Varaico: Literature-Extracted Genetic Variants

LCK

326 papers

RefSeq Summary

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-termina...

Pfam Domains

SH3_1aa 67–113UCSCSH3 domain

SH2aa 127–209UCSCSH2 domain

PK_Tyr_Ser-Thraa 245–494UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

LCK proto-oncogene, Src family tyrosine kinase

HGNC Previous Name

lymphocyte-specific protein tyrosine kinase

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_005356.5

p.A396V

c.1187C>T

Surrounding Variants

2 papers

NM_005356.5

p.A396T

c.1186G>A

1 paper

NM_005356.5

p.R397R

c.1191G>A

1 paper

NM_005356.5

p.Y394*

c.1182C>A

1 paper

NM_005356.5

p.Y394*

c.1182C>G

5 papers

NM_005356.5

p.Y394F

c.1181A>T

1 paper

NM_005356.5

p.E393G

c.1178A>G

1 paper

NM_005356.5

p.G399E

c.1196G>A

2 papers

NM_005356.5

p.L388F

c.1162C>T

1 paper

NM_005356.5

p.R387C

c.1159C>T

1 paper

NM_005356.5

p.D382E

c.1146C>A

1 paper

NM_005356.5

p.D382E

c.1146C>G

1 paper

NM_005356.5

p.K379N

c.1137G>C