Varaico: Literature-Extracted Genetic Variants

Gene:LEP
Variant:p.D61Y

LEP

798 papers

RefSeq Summary

This gene encodes a protein that is secreted by white adipocytes into the circulation and plays a major role in the regulation of energy homeostasis. Circulating leptin binds to the leptin receptor in...

Pfam Domains

Leptinaa 23–167UCSCLeptin

Gene Aliases

HGNC Name

leptin

HGNC Previous Symbols

OBS; OB

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_000230.3
p.D61Y
c.181G>T
Surrounding Variants
1 paper
NM_000230.3
p.D61N
c.181G>A
1 paper
NM_000230.3
p.D61H
c.181G>C
2 papers
NM_000230.3
p.D61A
c.182A>C
4 papers
NM_000230.3
p.F62C
c.185T>G
2 papers
NM_000230.3
p.I63L
c.187A>C
7 papers
NM_000230.3
p.G59S
c.175G>A
1 paper
NM_000230.3
p.G59C
c.175G>T
1 paper
NM_000230.3
p.T58S
c.173C>G
1 paper
NM_000230.3
p.T58S
c.172A>T
5 papers
NM_000230.3
p.P64S
c.190C>T
1 paper
NM_000230.3
p.P64H
c.191C>A
2 papers
NM_000230.3
p.V57V
c.171C>T
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